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Regulatory network of the allosteric ATP inhibition of E. coli phosphofructokinase-2 studied by hybrid dimers
(Elsevier B.V., 2016)
© 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM) We have proposed an allosteric ATP inhibition mechanism of Pfk-2 determining the structure of different forms of the enzyme together ...
Intrinsic allosteric inhibition of signaling proteins by targeting rare interaction states detected by high-pressure NMR spectroscopy
(Wiley-VCH VerlagWeinheim, 2013-12)
A new type of allosteric inhibition by small molecules is proposed that should be applicable to all proteins involved intrinsically in protein-protein interactions. It is based on targeting their rare interaction states ...
Dissecting a novel allosteric mechanism of cruzain: A computer-aided approach
(Public Library Science, 2019-01-25)
Trypanosoma cruzi is the causative agent of Chagas disease, a neglected infection affecting millions of people in tropical regions. There are several chemotherapeutic agents for the treatment of this disease, but most of ...
Regulatory network of the allosteric ATP inhibition of E. coli phosphofructokinase-2 studied by hybrid dimers
(2016)
We have proposed an allosteric ATP inhibition mechanism of Pfk-2 determining the structure of different forms of the enzyme together with a kinetic enzyme analysis. Here we complement the mechanism by using hybrid oligomers ...
Regulation of thrombin activity with ultrasmall nanoparticles: effects of surface chemistry
(American Chemical Society, 2020-06-26)
Nanomaterials displaying well-tailored sizes and surface chemistries can provide novel ways with which to modulate the structure and function of enzymes. Recently, we showed that gold nanoparticles (AuNPs) in the ultrasmall ...
A Novel Dual Allosteric Activation Mechanism of Escherichia coli ADP-glucose Pyrophosphorylase: The role of pyruvate
(Public Library Of Science, 2014-07)
Fructose-1,6-bisphosphate activates ADP-glucose pyrophosphorylase and the synthesis of glycogen in Escherichia coli. Here, we show that although pyruvate is a weak activator by itself, it synergically enhances the ...
Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds
(American Chemical Society, 2018-08)
The Polo-like kinases (Plks) are an evolutionary conserved family of Ser/Thr protein kinases that possess, in addition to the classical kinase domain at the N-terminus, a C-terminal polo-box domain (PBD) that binds to ...
The crystal complex of phosphofructokinase-2 of escherichia coli with fructose-6-phosphate kinetic and structural analysis of the allosteric atp inhibition
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2011)
Allosteric substrate inhibition of Arabidopsis NAD-dependent malic enzyme 1 is released by fumarate
(Elsevier, 2015-02)
Plant mitochondria can use L-malate and fumarate, which accumulate in large levels, as respiratory substrates. In part, this property is due to the presence of NAD-dependent malic enzymes (NAD-ME) with particular biochemical ...