Search
Now showing items 1-10 of 320
Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation
(Endocrine Society, 2007-08)
Transgenic (TG) mice expressing human chorionic gonadotropin (hCG) beta-subunit under the ubiquitin C promoter, presenting with a moderately elevated level of LH/hCG bioactivity develop multiple neoplasms secondary to the ...
Wnt-5a/frizzled9 receptor signaling through the Gαo-Gβγ complex regulates dendritic spine formation
(American Society for Biochemistry and Molecular Biology, 2016-09)
Wnt ligands play crucial roles in the development and regulation of synapse structure and function. Specifically, Wnt-5a acts as a secreted growth factor that regulates dendritic spine formation in rodent hippocampal ...
The emerging role of Wnt5a in the promotion of a pro-inflammatory and immunosuppressive tumor microenvironment
(Springer, 2020-05-20)
Wnt5a is the prototypical activator of the non-canonical Wnt pathways, and its overexpression has been implicated in the progression of several tumor types by promoting cell motility, invasion, EMT, and metastasis. Recent ...
Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia
(Elsevier Ireland, 2017-01)
In androgenetic alopecia, androgens impair dermal papilla-induced hair follicle stem cell (HFSC) differentiation inhibiting Wnt signaling. Wnt agonists/antagonists balance was analyzed after dihydrotestosterone (DHT) ...
Importance of WNT-dependent signaling for derivation and maintenance of primed pluripotent bovine embryonic stem cells†
(Society for the Study of Reproduction, 2021-04)
The WNT signaling system plays an important but paradoxical role in the regulation of pluripotency. In the cow, IWR-1, which inhibits canonical WNT activation and has WNT-independentactions, promotes the derivation of ...
Neonatal exposure to a glyphosate-based herbicide alters uterine decidualization in rats
(Pergamon-Elsevier Science Ltd, 2017-10)
We investigated whether defective modulation of uterine signaling may cause decidualization failure in rats neonatally exposed to a glyphosate-based herbicide (GBH). Female pups received vehicle or 2 mg/kg of GBH from ...
Are changes in the wnt/b-catenin pathway involved in cocaine and stress-induced long-term neuroadaptations?
(Elyns Publishing group, 2017-10)
Drug addiction has been defined as a chronic relapsing brain disease, characterized by compulsive drug seeking and use, despite harmful consequences. This phenomenon has been extensively studied and the use of animal models ...
Wnt-7a Induces Presynaptic Colocalization of 7-Nicotinic Acetylcholine Receptors and Adenomatous Polyposis Coli in Hippocampal Neurons
(Society for Neuroscience, 2007-05-16)
Nicotinic acetylcholine receptors (nAChRs) contribute significantly to hippocampal function. Alpha7-nAChRs are present in presynaptic sites in hippocampal neurons and may influence transmitter release, but the factors that ...