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WNT16 is robustly increased by oncostatin m in mouse calvarial osteoblasts and acts as a negative feedback regulator of osteoclast formation induced by oncostatin M
(2021-01-01)
Background: Bone loss is often observed adjacent to inflammatory processes. The WNT signaling pathways have been implicated as novel regulators of both immune responses and bone metabolism. WNT16 is important for cortical ...
WNT signaling in neuronal maturation and synaptogenesis
(Frontiers, 2013-07)
The Wnt signaling pathway plays a role in the development of the central nervous system and growing evidence indicates that Wnts also regulates the structure and function of the adult nervous system. Wnt components are key ...
El receptor Ror1 y su rol en cancerThe role of Ror1 receptor in cancerO receptor Ror1 e seu papel em câncer
(Federación Bioquímica de la Provincia Buenos Aires, 2011-12)
Las proteínas Wnt son ligandos que activan señales involucradas en proliferación, sobrevida, adhesión, migración, diferenciación y polaridad celular y como tal están involucradas en una amplia variedad de patologías. A ...
Consequences of endogenous and exogenous WNT signaling for development of the preimplantation bovine embryo
(2017-01-01)
The specific role of WNT signaling during preimplantation development remains unclear. Here, we evaluated consequences of activation and inhibition of ß-catenin (CTNNB1)-dependent and -independent WNT signaling in the ...
Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage
(2013-03-01)
Objectives were to evaluate the role of canonical WNT signaling in development of the preimplantation embryo. Signaling was activated with 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine (AMBMP) ...
Non-canonical Wnt signalling and regulation of gastrulation movements
(Elsevier Ltd, 2002)
Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt ...
The Wnt signaling pathway and rheumatoid arthritis
(ELSEVIER SCIENCE BV, 2010)
The Wnt signaling pathways play a key role in cell renewal, and there are two such pathways. In patients with rheumatoid arthritis (RA), the synovial membrane expresses genes such as Wnt and Fz at higher levels than those ...
WNT-5A, but not matrix metalloproteinase 3 or beta-catenin protein, expression is related to early stages of lip carcinogenesis
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Background: Oncogenic Wnt/beta-catenin signaling occurs in numerous types of cancers, but little is known about the role of the Wnt protein family member, WNT-5A, in lip carcinogenesis. The aim of this study was to investigate ...
Insights from Studies with Oral Cleft Genes Suggest Associations between WNT-pathway Genes and Risk of Oral Cancer
(SAGE PUBLICATIONS INC, 2011)
Oral squamous cell carcinoma (OSCC) accounts for more than 90% of the malignant neoplasms that arise in the mucosa of the upper aerodigestive tract. Recent studies of cleft lip/palate have shown the association of genes ...
Wnt-regulated dynamics of positional information in zebrafish somitogenesis
(Company Of Biologists, 2014-03)
How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of ...