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Vesicular acetylcholine transporter knock-down mice are more susceptible to pilocarpine induced status epilepticus
(Elsevier B.V., 2008-05-09)
The pilocarpine (PILO) animal model of Temporal Lobe Epilepsy (TLE) portrays the most common changes in hippocampal circuitry found in human TLE. the acute cholinergic insult induces status epilepticus (SE), which triggers ...
RCAN1 knockdown reverts defects in the number of calcium-induced exocytotic events in a cellular model of down syndrome
(Frontiers Media, 2018-07-06)
In humans, Down Syndrome (DS) is a condition caused by partial or full trisomy of chromosome 21. Genes present in the DS critical region can result in excess gene dosage, which at least partially can account for DS phenotype. ...
Evaluation of the effects of PhKv toxin, isolated from the Phoneutria nigriventer venom, on memory, in mice deficient for the vesicular acetylcholine transporter
(Universidade Federal de Minas GeraisBrasilMEDICINA - FACULDADE DE MEDICINAPrograma de Pós-Graduação em Medicina MolecularUFMG, 2022-02-21)
A acetilcolina (ACh) é um neurotransmissor importante para a cognição. Dentre diversas funções, ela atua como reguladora de circuitos relacionados à atenção, flexibilidade cognitiva, memória e interação social. Níveis ...
Effects of VAChT reduction and α7nAChR stimulation by PNU-282987 in lung inflammation in a model of chronic allergic airway inflammation
(Elsevier, 2020-09-05)
The cholinergic anti-inflammatory pathway has been shown to regulate lung inflammation and cytokine release in acute models of inflammation, mainly via α7 nicotinic receptor (α7nAChR). We aimed to evaluate the role of ...
Pulmonary Inflammation Is Regulated by the Levels of the Vesicular Acetylcholine Transporter
(Public Library Science, 2015-03-27)
Acetylcholine (ACh) plays a crucial role in physiological responses of both the central and the peripheral nervous system. Moreover, ACh was described as an anti-inflammatory mediator involved in the suppression of exacerbated ...
Sinais de tráfego envolvidos no envolvidos no endereçamento do transportador vesicular de acetilcolina (VAChT)
(Universidade Federal de Minas GeraisUFMG, 2006-04-17)
The vesicular acetylcholine transporter (VAChT) is the protein responsible for packaging cytoplasmic acetylcholine (ACh) into the synaptic vesicle of cholinergic neurons. The cytosolic C-terminal region of VAChT is important ...
Análise do efeito do extrato padronizado de Ginkgo biloba na memória em camundongos com redução do transportador vesicular de acetilcolina (VAChT)
(Universidade Federal de São Paulo, 2019)
O transportador vesicular de acetilcolina (VAChT) é necessário para as funções
do sistema colinérgico no sistema nervoso central e periférico, pois participa da etapa
crucial para o armazenamento da acetilcolina (ACh). ...
Increased Cholinergic Tone Causes Pre-synaptic Neuromuscular Degeneration and is Associated with Impaired Diaphragm Function
(2021-04-15)
In vertebrates, muscle activity is dependent on acetylcholine (ACh) released from neuromuscular junctions (NMJs), and changes in cholinergic neurotransmission are linked to a variety of neuromuscular diseases, including ...