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Does the tumour microenvironment alter tumorigenesis and clinical response in transmissible venereal tumour in dogs?
(2018-09-01)
The canine transmissible venereal tumour (CTVT) is a transmissible cancer that is spread naturally between dogs, with the ability to develop and evade the immune system, despite strict immune surveillance of the host. ...
Metastatic immune infiltrates correlate with those of the primary tumour in canine osteosarcoma
(2019-01-01)
Our lack of understanding of the immune microenvironment in canine osteosarcoma (cOSA) has limited the identification of potential immunotherapeutic targets. In particular, our ability to utilize readily available tissue ...
Metronomic chemotherapy in small animal practice: An update
(2016-01-01)
Metronomic chemotherapy can be considered a new chemotherapy modality involving continuous administration of low doses of cytostatic agents which targets endothelial cells. Endothelial cells are vital for the development ...
Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy
(2010-05-13)
Abstract
Background
Phagocytosis of apoptotic cells by macrophages induces a suppressor phenotype. Previous data from our group suggested that this occurs via Platelet-activating ...
Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy
(2010-05-13)
Abstract
Background
Phagocytosis of apoptotic cells by macrophages induces a suppressor phenotype. Previous data from our group suggested that this occurs via Platelet-activating ...
Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma
(2018-01-01)
Immunotherapeutic strategies have shown promise for the treatment of canine osteosarcoma (cOSA). Very little is known about the immune microenvironment within cOSA, however, limiting our ability to identify potential immune ...
T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour
(Blackwell Publishing, 2013)
T helper type 17 (Th17) lymphocytes are found in high frequency in
tumour-burdened animals and cancer patients. These lymphocytes, characterized
by the production of interleukin-17 and other pro-inflammatory
cytokines, ...
Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy
(LONDON, 2010)
Abstract
Background
Phagocytosis of apoptotic cells by macrophages induces a suppressor phenotype. Previous data from our ...
Involvement of formyl peptide receptors in the stimulatory effect of crotoxin on macrophages co-cultivated with tumour cells
(Pergamon PressOxford, 2013-11)
Crotoxin (CTX) is the main neurotoxic component of Crotalus durissus terrificus snake venom. It inhibits tumour growth and modulates the function of macrophages, which are essential cells in the tumour microenvironment. ...