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Differential response of myeloid-derived suppressor cells to the nonsteroidal anti-inflammatory agent indomethacin in tumor-associated and tumor-free microenvironments
(American Association of Immunologists, 2015-04-01)
Myeloid-derived suppressor cells (MDSCs) are key regulatory cells that control inflammation and promote tumor-immune escape. To date, no specific immunomodulatory drug has proven efficacy in targeting the expansion and/or ...
The inflammatory profile of the tumor microenvironment, orchestrated by cyclooxygenase-2, promotes epithelial- mesenchymal transition
(Frontiers Media, 2021)
The tumor microenvironment (TME) corresponds to a complex and dynamic
interconnection between the extracellular matrix and malignant cells and their
surrounding stroma composed of immune and mesenchymal cells. The TME ...
NFAT1 transcription factor is central in the regulation of tissue microenvironment for tumor metastasis
(SPRINGER, 2011)
Members of the nuclear factor of activated T cell (NFAT) family of transcription factors were originally described in T lymphocytes but later shown to be expressed in several immune and non-immune cell types. NFAT proteins ...
Changes In The Microenvironment Of Invading Melanoma And Carcinoma Cells Identified By Ftir Imaging
(ELSEVIER SCIENCE BVAMSTERDAM, 2015)