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Key proteins in the polyamine-trypanothione pathway as drug targets against Trypanosoma cruzi
(Bentham Science Publishers B.V., 2014)
In trypanosomatids, redox homeostasis is centered on trypanothione (N 1,N8-bis(glutathionyl)spermidine, T(SH)2), a low molecular weight thiol that is distinctive for this taxonomic family and not present in the mammalian ...
Trypanosomatidae diseases: from the current therapy to the efficacious role of trypanothione reductase in drug discovery
(Bentham Science Publishers, 2018)
Trypanosomatidae Diseases: From the Current Therapy to the Efficacious Role of Trypanothione Reductase in Drug Discovery
(Bentham Science Publishers, 2021)
Molecular Dynamics Simulations of Peptide Inhibitors Complexed With Trypanosoma cruzi Trypanothione Reductase
(2012)
The drugs against tropical neglected diseases, especially Chagas’ Disease, were launched more than 30 years ago, and the development of resistance requires the discovery of new and more effective chemotherapeutic agents. ...
Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi
(Society of Biology of Chile, 2004)
Proteins rich in sulfhydryl groups, such as metallothionein, are present in several strains of the parasite Trypanosoma cruzi, the etiological agent of Chagas' disease. Metallothionein-like protein concentrations ranged ...
Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi.
(Sociedad de Biología de Chile, 2004)