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TRPC channels are not required for graded persistent activity in entorhinal cortex neurons
(Veterinary and Human Toxicology, 2019-11)
Adaptive behavior requires the transient storage of information beyond the physical presence of external stimuli. This short-lasting form of memory involves sustained (“persistent”) neuronal firing which may be generated ...
TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice
(Sci Rep, 2017-08)
Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure ...
Angiotensin-II-evoked Ca2+ entry in murine cardiac gibroblasts does not depend on TRPC channels
(MDPI, 2020)
Abstract: TRPC proteins form cation conducting channels regulated by different stimuli and are regulators of the cellular calcium homeostasis. TRPC are expressed in cardiac cells including cardiac fibroblasts (CFs) and ...
Angiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli
(Nature Publishing Group, 2014-09)
A key role for podocytes in the pathogenesis of proteinuric renal diseases has been established. Angiotensin II causes depolarization and increased intracellular calcium concentration in podocytes; members of the cation ...
TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice
(Nature Research, 2017)
Abstract: Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates ...
TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice
(Wiley Blackwell Publishing, Inc, 2017-02)
Objective: Canonical transient receptor potential (TRPC) channels constitute a family of cation channels that exhibit a regional and cell-specific expression pattern throughout the brain. It has been reported previously ...
Human Digital Meissner Corpuscles Display Immunoreactivity for the Multifunctional Ion Channels Trpc6 and Trpv4
(Blackwell Publishing Inc., 2017)
Reduced endoplasmic reticulum stress-induced apoptosis and impaired unfolded protein response in TRPC3-deficient M1 macrophages
(American Physiological Society, 2014-09)
Endoplasmic reticulum (ER) stress is a prominent mechanism of macrophage apoptosis in advanced atherosclerotic lesions. Recent studies from our laboratory showed that advanced atherosclerotic plaques in Apoe-/- mice with ...
Transient receptor potential canonical type 3 channels control the vascular contractility of mouse mesenteric arteries
(Public Library of Science, 2014-10)
Transient receptor potential canonical type 3 (TRPC3) channels are non-selective cation channels and regulate intracellular Ca2+ concentration. We examined the role of TRPC3 channels in agonist-, membrane depolarization ...