Now showing items 1-10 of 176
Translation controlled mRNAs: New drug targets in infectious diseases?
(Bentham Science Publishers B.V., 2009)
Recent data from a series of laboratories has pinpointed the relevant role of translation control on the regulation of gene expression. In particular, an analysis of T cell activation has led to demonstrate that during ...
DISC1 promotes translation maintenance during sodium arsenite-induced oxidative stress
(Elsevier B.V., 2019)
Variation in Disrupted-in-Schizophrenia 1 (DISC1) increases the risk for neurodegenerative diseases, schizophrenia, and other mental disorders. However, the functions of DISC1 associated with the development of these ...
Challenges in translating interview protocols for alleged child victims of sexual abuse to different languages: A case study
(Elsevier Ltd, 2019)
Adequate interviewing of alleged victims of child sexual abuse is critical for the investigation and for preserving the welfare of the child. Investigative interview protocols for children (IIPCs) have been developed to ...
Finite topology self-translating surfaces for the mean curvature flow in R3
Finite topology self-translating surfaces for the mean curva-ture flow constitute a key element in the analysis of TypeII singularities from a compact surface because they arise as lim-its after suitable blow-up scalings ...
Reflections of L1 reading comprehension skills in university academic grades for an undergraduate translation programme
(Taylor and Francis Ltd., 2019)
Concerns about poor L1 reading skills in undergraduate students have been expressed in several contexts. These skills form a basis for building robust L2 reading comprehension skills, vital for translators. This study, ...
Neurotoxins as Preclinical Models for Parkinson’s Disease
(Springer New York LLC, 2018)
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.Translational medicine is one of the major concerns in this century. While significant advances have been made with scientific knowledge, the translation ...
DEAD-box RNA helicase DDX3 connects CRM1-dependent nuclear export and translation of the HIV-1 unspliced mRNA through its N-terminal domain
DEAD-box RNA helicase DDX3 is a host factor essential for HIV-1 replication and thus, a potential target for novel therapies aimed to overcome viral resistance. Previous studies have shown that DDX3 promotes nuclear ...
Global translational impacts of the loss of the tRNA modification t(6)A in yeast
(SHARED SCIENCE PUBLISHERS, 2016)
The universal tRNA modification t(6)A is found at position 37 of nearly all tRNAs decoding ANN codons. The absence of t(6)A(37) leads to severe growth defects in baker's yeast, phenotypes similar to those caused by defects ...
Codon evolution and conservation of the reading phase in genetic code translation
The description of the optimized evolution of a code based on 4 nucleotides involves a sequential transition of codons, formed firstly by monomers evolving to dimers and then to triplets, in accordance with the progressive ...
Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts
(Oxford University Press, 2017-06)