Now showing items 1-10 of 340
Antiviral activity of phosphonoformate on rotavirus transcription and replication
The antiviral effect of foscarnet (PFA) on the replication of rotavirus, a member of the Reoviridae, was studied. The pyrophosphate analogue is an effective inhibitor of several viral polymerases acting on the enzyme ...
Nuclear actin and myosins in adenovirus infection
(Elsevier Inc, 2015-11)
Adenovirus serotypes have been shown to cause drastic changes in nuclear organization, including the transcription machinery, during infection. This ability of adenovirus to subvert transcription in the host cell facilitates ...
UNFOLDED PROTEIN RESPONSE TRANSCRIPTION FACTOR XBP-1 DOES NOT INFLUENCE PRION REPLICATION OR PATHOGENESIS
(NATL ACAD SCIENCES, 2009)
Reverse Transcription Errors and RNA-DNA Differences at Short Tandem Repeats
Transcript variation has important implications for organismal function in health and disease. Most transcriptome studies focus on assessing variation in gene expression levels and isoform representation. Variation at the ...
Resistance to ultraviolet-induced apoptosis in DNA repair deficient growth arrested human fibroblasts is not related to recovery from RNA transcription blockage
(ELSEVIER SCIENCE BV, 2008)
The impact of ultraviolet (UV-C) photoproducts on apoptosis induction was investigated in growth arrested (confluent) and proliferating human primary fibroblasts. Confluent fibroblasts were more resistant to UV-C-induced ...
Synthetic Tumor-Specific Promoters for Transcriptional Regulation of Viral Replication
(Humana Press, 2017-08)
Here we describe a collection of methods that have been adapted to isolate and modify tumor-specific promoters (TSPs) to drive viral replication for cancer therapy and other uses. We will describe as examples the secreted ...
The arabidopsis DNA polymerase δ has a role in the deposition of transcriptionally active epigenetic marks, development and flowering
(Public Library Of Science, 2015-02)
DNA replication is a key process in living organisms. DNA polymerase α (Polα) initiates strand synthesis, which is performed by Polε and Polδ in leading and lagging strands, respectively. Whereas loss of DNA polymerase ...
Differential expression of a retrotransposable element, Rex6, in Colossoma macropomum fish from different Amazonian environments
(Mobile Genetic Elements, 2014)
Transposable elements (TEs) are DNA sequences that have the ability to move and replicate within the genomes. TEs can be classified according to their intermediates of transposition, RNA (retrotransposons) or DNA. In some ...
Massive depletion of bovine leukemia virus proviral clones located in genomic transcriptionally active sites during primary infection
(Public Library of Science, 2013-10)
Deltaretroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) induce a persistent infection that remains generally asymptomatic but can also lead to leukemia or lymphoma. These viruses ...