Search
Now showing items 1-10 of 3384
Cooperative RNA Polymerase Molecules Behavior on a Stochastic Sequence-Dependent Model for Transcription Elongation
(2013-02-21)
The transcription process is crucial to life and the enzyme RNA polymerase (RNAP) is the major component of the transcription machinery. The development of single-molecule techniques, such as magnetic and optical tweezers, ...
Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment
(Elsevier, 2017)
The genetic basis of earlobe attachment has been a matter of debate since the early 20th century, such that geneticists argue both for and against polygenic inheritance. Recent genetic studies have identified a few loci ...
Chimeric transcripts resulting from complex duplications in chromosome Xq28
(Springer-Verlag, 2016)
Identification and complete sequencing of novel human transcripts through the use of mouse orthologs and testis cDNA sequences
(2004-12-01)
The correct identification of all human genes, and their derived transcripts, has not yet been achieved, and it remains one of the major aims of the worldwide genomics community. Computational programs suggest the existence ...
Identification and complete sequencing of novel human transcripts through the use of mouse orthologs and testis cDNA sequences
(2004-12-01)
The correct identification of all human genes, and their derived transcripts, has not yet been achieved, and it remains one of the major aims of the worldwide genomics community. Computational programs suggest the existence ...
New insights into the regulatory mechanisms of ppGpp and DksA on Escherichia coli RNA polymerase-promoter complex
(Oxford University Press, 2015)
The stringent response modulators, guanosine tetraphosphate (ppGpp) and protein DksA, bind RNA polymerase (RNAP) and regulate gene expression to adapt bacteria to different environmental conditions. Here, we use Atomic ...
Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks
(Current Biology Ltd, 2014-08)
Gene expression programs activated in response to, or in anticipation of, environmental changes involve sequential steps, from transcription and RNA processing to nuclear export and translation. Here we review recent ...
Cooperative RNA Polymerase Molecules Behavior on a Stochastic Sequence-Dependent Model for Transcription Elongation
(2013-02-21)
The transcription process is crucial to life and the enzyme RNA polymerase (RNAP) is the major component of the transcription machinery. The development of single-molecule techniques, such as magnetic and optical tweezers, ...