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Understanding the structure and function of Bacillus thuringiensis toxins
(Pergamon-Elsevier Science Ltd, 2016-01)
As biological control agents take an expanding share of the pesticides market and the production of insect-resistant crops increases, it is essential to understand the structure and function of the active agents, the ...
Toxin-antitoxin systems and its biotechnological applications
(2014)
Toxin-antitoxin (TA) systems are important genetic modules composed by two elements: a toxin, that is always a protein, and an antitoxin, that can be a RNA or a protein and neutralizes the toxic effect of toxin. These ...
A natural combinatorial chemistry strategy in acylpolyamine toxins from Nephilinae orb-web spiders
(Taylor & Francis Inc, 2005-01-01)
The present study shows how nature combined a small number of chemical building blocks to synthesize the acylpolyamine toxins in the venoms of Nephilinae orb-web spiders. Considering these structures in four parts, it was ...
Crystal structure of Staphylococcus aureus exfoliative toxin D-like protein: structural basis for the high specificity of exfoliative toxins
(Elsevier B. V., 2015-11-06)
Exfoliative toxins are serine proteases secreted by Staphylococcus aureus that are associated with toxin-mediated staphylococcal syndromes. To date, four different serotypes of exfoliative toxins have been identified and ...
Characterization of an OrtT-like toxin of Salmonella enterica serovar Houten
(Springer, 2019-07-01)
The Escherichia coli GhoT/GhoS system is a type V toxin-antitoxin system in which the antitoxin GhoS cleaves the GhoT mRNA, controlling its translation. GhoT is a small hydrophobic protein that damages bacterial membranes. ...
Shiga toxins and stx phages: highly diverse entities
(Society for General Microbiology, 2015-03)
Shiga toxins are the main virulence factors of a group of Escherichia coli strains [Shiga toxin-producing E. coli (STEC)] that cause severe human diseases, such as haemorrhagic colitis and haemolytic–uraemic syndrome. The ...
Effects of Clostridium perfringens iota toxin in the small intestine of mice
(Elsevier, 2017-12)
Iota toxin is a binary toxin solely produced by Clostridium perfringens type E strains, and is structurally related to CDT from C. difficile and CST from C. spiroforme. As type E causes hemorrhagic enteritis in cattle, it ...
Standardization of the PCR technique for the detection of delta toxin in Staphylococcus spp.
(Centro de Estudos de Venenos e Animais Peçonhentos, 2005-06)
Coagulase-negative staphylococci (CNS), components of the normal flora of neonates, have emerged as important opportunistic pathogens of nosocomial infections that occur in neonatal intensive care units. Some authors have ...