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Impaired thymic output can be related to the low immune reconstitution and T cell repertoire disturbances in relapsing visceral leishmaniasis associated HIV/AIDS patients
(Universidade Federal de Minas GeraisBrasilHCL - HOSPITAL DAS CLINICASUFMG, 2020-05-20)
Introdução: Leishmaniose visceral/coinfectados pelo HIV (LV/LV) representam cerca de 8% dos casos notificados de LV no Brasil. As recidivas da infecção por Leishmania após tratamento antileishmania constituem um grande ...
Cathepsin-L influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number
(American Association of Immunologists, 2005-12)
Nackt mice, which are deficient in cathepsin-L (CTSL), show an early impairment during positive selection in the context of class II MHC molecules and as a consequence, the percentage and absolute number of CD4(+) thymocytes ...
Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number"
(American Association of Immunologists, 2006-12)
In our article published in The Journal of Immunology in June 1, 2005 (1), we reported that lymph nodes from nackt mice (CTSLnkt/CTSLnkt) are hypertrophied, showing a normal absolute number of CD4+ T cells and a marked ...
The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation
(Frontiers Media, 2020)
Chagas disease, caused by the protozoan parasite T. cruzi, is a prevalent parasitic disease in Latin America. Presently, it is spreading around the world by human migration, thus representing a new global health issue. ...
Decreased number of T cells bearing TCR rearrangement excision circles (TREC) in active recent onset systemic lupus erythematosus
(Arnold, Hodder Headline PlcLondonInglaterra, 2004)
B-cell lymphopoiesis is influenced by cathepsin L
(Public Library Science, 2013-04)
Cathepsin L (CTSL) is a ubiquitously expressed lysosomal cysteine peptidase with diverse and highly specific functions. The involvement of CTSL in thymic CD4+ T-cell positive selection has been well documented. Using ...
Aumento de linfocitos T regulatorios en los ganglios linfoides de ratones mutantes para catepsina LIncrease of regulatory T cells in the lymph node of cathepsin L mutant mice
(Medicina (Buenos Aires), 2011-04)
Las células T regulatorias CD4+CD25+Foxp3+ (Treg) han sido implicadas en el rechazo al trasplante de órganos alogeneicos, en cáncer, infecciones y enfermedades autoinmunes. Así, su modulación posee un enorme potencial para ...