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Differential uPA expression by TGF-beta 1 in gingival fibroblasts
(INT AMER ASSOC DENTAL RESEARCHI A D R/A A D R, 2006-02)
Transforming Growth Factor-beta 1 (TGF-beta 1) plays a key role in connective tissue remodeling and inflammation. Under pathological conditions, like periodontal disease, fibroblasts may display an altered response to this ...
Fine-Tuning the TGF beta Signaling Pathway by SARA During Neuronal Development
(Frontiers Media, 2020)
Neural development is a complex process that involves critical events, including cytoskeleton dynamics and selective trafficking of proteins to defined cellular destinations. In this regard, Smad Anchor for Receptor ...
JNK mediates TGF-beta 1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes
(ELSEVIER, 2006-10-02)
In this study we analyzed the role of the c-Jun N-terminal kinases (JNK) pathway in the TGF-beta 1 stimulation of urokinase-type plasminogen activator (uPA), initial stages of epithelial-mesenchymal transdifferentiation ...
Role of dihydrotestosterone (DHT) on TGF‑β1 signaling pathway in epithelial ovarian cancer cells
(Springer, 2016)
Purpose One of the hypotheses regarding the genesis of epithelial ovarian cancer involves the action of androgens on the proliferation of epithelial ovarian cells, as well as inclusion cysts. The purpose of the present ...
Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-β1
(Elsevier, 2020)
Cardiac fibroblasts (CFs) are necessary to maintain extracellular matrix (ECM) homeostasis in the heart. Normally, CFs are quiescent and secrete small amounts of ECM components, whereas, in pathological conditions, they ...
Mating Decreases Plasma Levels of TGF beta 1 and Regulates Myosalpinx Expression of TGF beta 1/TGFBR3 in the Rat
(Wiley, 2014)
Mating shuts down a 2-methoxyestradiol (2ME)-dependent, non-genomic activity that is responsible for accelerating egg transport in the rat oviduct. The aims of this work were to investigate the role of TGF1 in this 2ME-reduced ...
Lipopolysaccharide activates toll like receptor 4 and prevents cardiac fibroblast to myofibroblast differentiation
(Springer, 2017)
Bacterial lipopolysaccharide (LPS) is a known ligand of Toll-like receptor 4 (TLR4) which is expressed in cardiac fibroblasts (CF). Differentiation of CF to cardiac myofibroblasts (CMF) is induced by transforming growth ...
Immature rat ovaries become revascularized rapidly after autotransplantation and show a gonadotropin-dependent increase in angiogenic factor gene expression
(Endocrine Society, 1994)
When the ovaries of 23-day-old juvenile rats are transplanted to an ectopic site, they recover within 1 week the ability to control gonadotropin secretion via steroid negative feedback. Vascular corrosion casting followed ...
Augmented cell survival in eutopic endometrium from women with endometriosis: Expression of c-myc, TGF-betaI and bax genes
(BIOMED CENTRAL LTD, 2005-09-08)
Background: Endometriosis is a common gynaecological disorder characterized by the presence of endometrial tissue outside of the uterus. The fragments in normal menstruation are composed of necrotic and living cells, which ...
A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-β+ tolerogenic dendritic cells
(2011)
We have previously demonstrated that IT9302, a nonameric peptide homologous to the C-terminal domain of human IL-10, mimics several effects of the cytokine including down-regulation of the antigen presentation machinery ...