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Testicular steroid sulfatase overexpression is associated with Leydig cell dysfunction in primary spermatogenic failure
(Wiley, 2021)
Background Decreased testosterone (T) to LH ratio and increased 17 beta-estradiol (E2) serum concentrations represent a common finding among patients with severe spermatogenic failure, suggesting a concurrent Leydig cell ...
Low risk of impaired testicular sertoli and Leydig cell functions in boys with isolated hypospadias
(ENDOCRINE SOC., 2005-11)
Testicular dysfunction was observed in 57.1% and androgen end- organ defects in 7.2% of patients with hypospadias associated with cryptorchidism, micropenis, or ambiguous genitalia. In the remaining 35.7%, the disorder was ...
P450-aromatase activity and expression in human testicular tissues with severe spermatogenic failure
(Blackwell Publishing Ltd, 2010)
There is evidence that impaired spermatogenesis is associated with an imbalance in the oestradiol/testosterone ratio and with Leydig cell (LC) dysfunction. In testis, P450-aromatase, encoded by CYP19, is responsible for ...
Overexpression of CYP19A1 aromatase in Leydig cells is associated with steroidogenic dysfunction in subjects with Sertoli cell-only syndrome
(Blackwell Publishing Ltd, 2017)
© 2016 American Society of Andrology and European Academy of Andrology Several observational studies have showed a combination of lower testosterone (T) to LH ratio and higher estradiol (E2) to T ratio in secretory infertile ...
Resveratrol aumenta a motilidade espermática, previne a lipoperoxidação e melhora as defesas antioxidantes em testículos de ratos hipertireóideos
(Universidade Federal de Santa MariaBRFarmacologiaUFSMPrograma de Pós-Graduação em Farmacologia, 2012-07-20)
Hyperthyroidism may lead to an increase in oxidative stress (OS) in testis, may cause male reproductive disorders, among them, the loss in the sperm quality. The effect of resveratrol (RSV) on sperm motility and on OS ...
Systemic arterial hypertension leads to decreased semen quality and alterations in the testicular microcirculation in rats
(2019-12-01)
Arterial hypertension is a cardiovascular disease that leads to important systemic alterations and drastically impairs normal organ function over time. Hypertension affects around 700 million men of reproductive age and ...
Afectación de la función testicular en niños con criptorquidiaTesticular dysfuntion in boys with cryptorchidism
(Asociación de Profesionales del Hospital de Niños Ricardo Gutiérrez, 2018-10)
Poca atención se ha puesto en la capacidad funcional del testículo en los niños con criptorquidia. La Hormona Anti-Mülleriana (AMH) producida por la célula de Sertoli es el marcador ideal para evaluar la función testicular ...
Male hypogonadism: an extended classification based on a developmental, endocrine physiology-based approach
(Wiley, 2013-01)
Normal testicular physiology results from the integrated function of the tubular and interstitial compartments. Serum markers of interstitial tissue function are testosterone and insulin-like factor 3 (INSL3), whereas ...
Efeitos do hipotireoidismo no sistema reprodutor masculino
(2012)
Thyroid hormones are essential for growth, development and metabolism in many tissues and organs. Currently, it is known that these hormones play an important activity in testicular function in several species through ...
Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosterone
(Springer, 2013-06)
The reprograming effects of prenatal testosterone (T) treatment on postnatal reproductive parameters have been studied extensively in females of several species but similar studies in males are limited. We recently found ...