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Post-translational incorporation of 3,4-dihydroxyphenylalanine into the C terminus of α-tubulin in living cells
(Wiley Blackwell Publishing, Inc, 2018-03)
The C-terminal tyrosine (Tyr) of the α-tubulin chain is subjected to post-translational removal and readdition in a process termed the “detyrosination/tyrosination cycle”. We showed in previous studies using soluble rat ...
Irreversible incorporation of L-dopa into the C-terminus of α-tubulin inhibits binding of molecular motor KIF5B to microtubules and alters mitochondrial traffic along the axon
(Academic Press Inc Elsevier Science, 2021-01)
L-dopa is the most effective drug used to date for management of Parkinson's disease symptoms. Unfortunately, long-term administration of L-dopa often results in development of motor disorders, including dyskinesias. Despite ...
Helicity of α(404-451) and β(394-445) tubulin C-terminal recombinant peptides
(1999)
We have investigated the solution conformation of the functionally relevant C-terminal extremes of α- and β-tubulin, employing the model recombinant peptides RL52α3 and RL33β6, which correspond to the amino acid sequences ...
Population replacement of benzimidazole-resistant Haemonchus contortus with susceptible strains: evidence of changes in the resistance status
(Springer, 2022-07-02)
The spread of anthelmintic resistance (AR) in nematode populations threatens the viability of sheep production systems worldwide, and warrants the adoption of sensitive, practical, and standardized tests to detect AR. The ...
Análise genética de isolados do Haemonchus sp de ruminantes domésticos para identificação da resistência ao anti-helmíntico Benzimidazol
(Universidade Federal de Minas GeraisUFMG, 2012-03-12)
The purpose of this study is to genetically characterize the resistance to benzimidazole (BZ) anthelmintic in Haemonchus sp helminths isolated from ruminants. With this purpose, thirty animals from herds of cattle, goats, ...