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The absence of transthyretin does not impair regulation of lipid and glucose metabolism
(Georg Thieme Verlag KgStuttgartAlemanha, 2007)
Epidemiology of variant transthyretin amyloidosis at a reference center in Argentina
(Wiley, 2021-10)
Background: In Argentina, there is limited data of prevalence of variant transthyretin amyloidosis (ATTRv) and phenotype-genotype correlation. The laboratory of Hospital Italiano de Buenos Aires (HIBA) is a reference center ...
Structural and dynamics evidence for scaffold asymmetric flexibility of the human transthyretin tetramer
(Public Library of Science, 2017-12)
The molecular symmetry of multimeric proteins is generally determined by using X-ray diffraction techniques, so that the basic question as to whether this symmetry is perfectly preserved for the same protein in solution ...
Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity
(Nature Publishing Group, 2016-02)
Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR ...
Synthesis of transthyretin by the ependymal cells of the subcommissural organ
(SPRINGER SCIENCE, 2005)
Purification of transthyretin as nutritional biomarker of selenium status
(WILEY-V C H VERLAG GMBH, 2012)
Identification of a novel ligand binding motif in the transthyretin channel
(PERGAMON-ELSEVIER SCIENCE LTD, 2010)
The design of therapeutic compounds targeting transthyretin (TTR) is challenging due to the low specificity of interaction in the hormone binding site. Such feature is highlighted by the interactions of TTR with diclofenac, ...
Inhibition of human transthyretin aggregation by non-steroidal anti-inflammatory compounds: a structural and thermodynamic analysis
(MDPI AGBasel, 2013-03)
Transthyretin (TTR) is a homotetrameric protein that circulates in plasma and cerebral spinal fluid (CSF) whose aggregation into amyloid fibrils has been associated with at least two different amyloid diseases: senile ...