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Synthesis and pharmacological properties of TOAC-labeled angiotensin and bradykinin analogs
(Elsevier B.V., 2002-01-01)
Angiotensin II (AngII) and bradykinin (BK) derivatives containing the TOAC (2,2,6,6-tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid) spin label were synthesized by solid phase methodology. Ammonium hydroxide (pH 10, ...
Synthesis and pharmacological properties of TOAC-labeled angiotensin and bradykinin analogs
(Elsevier B.V., 2002-01-01)
Angiotensin II (AngII) and bradykinin (BK) derivatives containing the TOAC (2,2,6,6-tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid) spin label were synthesized by solid phase methodology. Ammonium hydroxide (pH 10, ...
Characterization of a conformationally sensitive TOAC spin-labeled substance P
(Elsevier B.V., 2008-11-01)
To probe the binding of a peptide agonist to a G-protein coupled receptor in native membranes, the spin-labeled amino acid analogue 4-amino-4-carboxy-2,2,6,6-tetramethyl-piperidino-1-oxyl (TOAC) was substituted at either ...
Conformational Properties of Angiotensin II and Its Active and Inactive TOAC-Labeled Analogs in the Presence of Micelles. Electron Paramagnetic Resonance, Fluorescence, and Circular Dichroism Studies
(JOHN WILEY & SONS INC, 2009)
The interaction between angiotensin II (AII, DRVYIHPF) and its analogs carrying 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid (TOAC) and detergents-negatively charged sodium dodecyl sulfate (SDS) and ...
Conformational studies of TOAC-labeled bradykinin analogues in model membranes
(Kluwer Academic Publ, 2002-01-01)
Spin-labeled analogues of bradykinin (BK) were synthesized containing the amino acid TOAC ( 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid) either before Arg(1) (TOAC(0)-BK) or replacing Pro(3) (TOAC(3)-BK). ...
Synthesis and pharmacological properties of TOAC-labeled angiotensin and bradykinin analogs
(Elsevier B.V., 2002-01-01)
Angiotensin II (AngII) and bradykinin (BK) derivatives containing the TOAC (2,2,6,6-tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid) spin label were synthesized by solid phase methodology. Ammonium hydroxide (pH 10, ...
Síntese e estudos biológicos conformacionais e enzimáticos de análogos da angiotensina I contendo marcador de spin toac
(Universidade Federal de São Paulo (UNIFESP), 2007)
Este trabalho iniciou um estudo conjugado abrangendo o enzimático com o de ressonância paramagnética eletrônica (RPE) de substratos peptídicos marcados paramagneticamente. A enzima conversora de angiotensina I (ECA, EC ...
Peptide-lipid interaction monitored by spin labeled biologically active melanocortin peptides
(Elsevier B.V., 2005-10-01)
The present work comparatively analyzes the interaction of alpha-MSH and its more potent and long-acting analog [Nle(4), D-Phe(7)]alpha-MSH (NDP-MSH) with lipid bilayers. the peptides were spin labeled with Toac ...
Conformational Properties of Angiotensin II and Its Active and Inactive TOAC-Labeled Analogs in the Presence of Micelles. Electron Paramagnetic Resonance, Fluorescence, and Circular Dichroism Studies
(Wiley-Blackwell, 2009-01-01)
The interaction between angiotensin II (AII, DRVYIHPF) and its analogs carrying 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid (TOAC) and detergents-negatively charged sodium dodecyl sulfate (SDS) and ...