Now showing items 1-10 of 323
Increased levels of rheumatoid factors after TNF inhibitor in rheumatoid arthritis
(Springer HeidelbergHeidelbergAlemanha, 2012)
Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
(Sociedad de Biología de Chile, 2008)
Targeted overexpression of tumor necrosis factor-a increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca21 influx in trigeminal neurons
(Lippincott Williams & Wilkins, 2016)
We reported earlier that TNF-alpha, a proinflammatory cytokine implicated in many inflammatory disorders causing orofacial pain, increases the activity of Cdk5, a key kinase involved in brain development and function and ...
Hypusine Modification of the Ribosome-binding Protein eIF5A, a Target for New Anti-Inflammatory Drugs: Understanding the Action of the Inhibitor GC7 on a Murine Macrophage Cell Line
(Bentham Science Publ Ltd, 2014-01-01)
Inflammation is part of an important mechanism triggered by the innate immune response that rapidly responds to invading microorganisms and tissue injury. One important elicitor of the inflammatory response is the Gram-negative ...
Is there a role for TNF-alpha antagonists in the treatment of SSc? EUSTAR expert consensus development using the Delphi technique
(Clinical & Exper RheumatologyPisaItália, 2011)
Effect of TNF-alpha on molecules related to the Iinsulin action in endometrial cells exposed to hyperandrogenic and hyperinsulinic conditions characteristics of polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) affects not only ovarian functions but is also able to affect endometrium metabolism. Around 80% of women with PCOS are obese. High tumor necrosis factor (TNF)- production and low adiponectin ...
TNF-alpha increases production of reactive oxygen species through Cdk5 activation in nociceptive neurons
(Frontiers Media SA, 2018)
The participation of reactive oxygen species (ROS) generated by NOX1 and NOX2/NADPH oxidase has been documented during inflammatory pain. However, the molecular mechanism involved in their activation is not fully understood. ...
Regulation of p21Waf1 expression and TNF alpha(biosynthesis by glutathione modulators in PMA induced-THP1 differentiation: Involvement of JNK and ERK pathways
(Elsevier B.V., 2007-11-30)
Oxidative modifications of proteins are fundamental biochemical events that regulate cellular signaling, protein expression, and function. the redox status is balanced by reductants in which GSH plays a major role. This ...
Diabetes reduces mesenchymal stem cells in fracture healing through a TNF alpha-mediated mechanism
Diabetes interferes with bone formation and impairs fracture healing, an important complication in humans and animal models. The aim of this study was to examine the impact of diabetes on mesenchymal stem cells (MSCs) ...
Biological evaluation of novel 6-arylbenzimidazo [1,2-c]quinazoline derivatives as inhibitors of LPS-induced TNF-alpha secretion
(SOC BIOLGIA CHILE, 2008)
This study describes the effect of novel 6-Arylbenzimidazo[1,2-c]quinazoline derivatives as tumor necrosis factor alpha (TNF-alpha) production inhibitors. The newly synthesized compounds were tested for their in vitro ...