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Combination of bioactive phytochemical and synthetic anthelmintics: in vivo and in vitro assessment of the albendazole-thymol association
(World Association for the Advancement of Veterinary Parasitology, 2019)
The search of novel strategies is an urgent need considering the widespread increasing of anthelmintic resistance in livestock. Bioactive phytochemicals may contribute to improve parasite control by enhancing the effect ...
Deciphering the molecular mechanisms underlying the anthelmintic effect of essential oils evaluated in Caenorhabditis elegans
(Genetics Society of America, 2021)
Helminths consist of a diverse group of parasitic worms including nematodes, which cause diseases of major socio-economic importance globally. Control of infections in both human and veterinary medicine currently relies ...
Activation and modulation of the caenorhabditis elegans serotonin-gated chloride channel
(Fundación Revista Medicina, 2019)
Serotonin-gated ion channels (5-HT3) belong to the family of Cys-loop receptors, which are pentameric proteins that mediate fast synaptic transmission. In mammals, 5- HT3 are non-selective cationic channels that can be ...
Monoterpenes as potential tools to improve the activity of synthetic anthelmintics: pharmacological screening of their effects on drug metabolism and intestinal accumulation
(World Association for the Advancement of Veterinary Parasitology, 2021)
The search for novel alternatives to control gastrointestinal nematodes in ruminants is relevant considering the increasing of anthelmintic resistance. The use of monoterpenes may contribute to improving parasite control ...
Integrated pharmacological evaluation of the combination of synthetic anthelmitics and bioactive phytochemicals: In-vitro and in vivo studies
(Fundación Revista Medicina, 2019)
In a context of increasing anthelmintic resistance, combination of synthetic anthelmintics with bioactive phytochemicals may be a pharmacological tool for improving the nematode control in livestock. The coadministration ...