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Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach
(Blackwell Publishing Inc., 2019)
Development of Magoh protein-overexpressing HEK cells for optimized therapeutic protein production
(Journal of the Serbian Chemical Society, 2020-04)
In the pharmaceutical industry, the need for high levels of protein expression in mammalian cells has prompted the search for new strategies, including technologies to obtain cells with improved mechanisms that enhance its ...
Deep Learning to Therapeutically Target Unreported Complexes
(Elsevier Science London, 2019-05-21)
The disruption of large protein–protein (PP) interfaces remains a challenge in targeted therapy. Designing drugs that compete with binding partners is daunting, especially when the structure of the protein complex is ...
Alzheimer's and prion disease as disorders of protein conformation: Implications for the design of novel therapeutic approaches
(1999)
Several lines of evidence suggest that a defective protein folding is a central event in both Alzheimer's and prion disease. Although the two disorders are very different clinically, neuropathologically, and biochemically, ...
In vivo bactericidal efficacy of gwh1 antimicrobial peptide displayed on protein nanoparticles, a potential alternative to antibiotics
(MDPI AG, 2020-12)
Oligomerization of antimicrobial peptides into nanosized supramolecular complexes produced in biological systems (inclusion bodies and self-assembling nanoparticles) seems an appealing alternative to conventional antibiotics. ...
Mechanisms, regulation and functions of the unfolded protein response
(Nature, 2020)
The unfolded protein response (UPR) comprises a network of signalling pathways that reprogramme transcription, translation and protein modifications to relieve the load of unfolded or misfolded proteins in the endoplasmic ...
Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development
The recent outbreak of the betacoronavirus SARS-CoV-2 has become a significant
concern to public health care worldwide. As of August 19, 2020, more than 22,140,472 people
are infected, and over 781,135 people have died ...