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Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons
(Frontiers Research Foundation, 2015-05-07)
Thalamocortical neurons are involved in the generation and maintenance of brain rhythms associated with global functional states. The repetitive burst firing of TC neurons at delta frequencies (1-4 Hz) has been linked to ...
Inward rectifier potassium current I Kir promotes intrinsic pacemaker activity of thalamocortical neurons
(American Physiological Society, 2018-06)
Slow repetitive burst firing by hyperpolarized thalamocortical (TC) neurons correlates with global slow rhythms (<4 Hz), which are the physiological oscillations during non-rapid eye movement sleep or pathological oscillations ...
Differential contribution of the subthreshold operating currents IT, Ih, and IKirto the resonance of thalamocortical neurons
(American Physiological Society, 2021-08)
Membrane potential oscillations of thalamocortical (TC) neurons are believed to be involved in the generation and maintenance of brain rhythms that underlie global physiological and pathological brain states. These membrane ...
Inward rectifier potassium current I Kir promotes the intrinsic pacemaker activity of thalamocortical neurons
(American Physiological Society, 2018-06)
Slow repetitive burst firing by hyperpolarized thalamocortical (TC) neurons correlates with global slow rhythms (< 4 Hz), which are the frequencies of the physiological oscillations during N-REMsleep, or pathological ones ...
Differential alterations of intracellular [Ca2+] dynamics induced by cocaine and methylphenidate in thalamocortical ventrobasal neurons
(Open Access Text, 2017-07)
The ventrobasal (VB) thalamus relay nucleus processes information from rodents? whiskers, projecting to somatosensory cortex. Cocaine and methylphenidate (MPH) have been described to differentially alter intrinsic properties ...
Leptin alters somatosensory thalamic networks by decreasing gaba release from reticular thalamic nucleus and action potential frequency at ventrobasal neurons
(Springer Heidelberg, 2018-06)
Leptin is an adipose-derived hormone that controls appetite and energy expenditure. Leptin receptors are expressed on extra-hypothalamic ventrobasal (VB) and reticular thalamic (RTN) nuclei from embryonic stages. Here, we ...
Propiedades intrínsecas y sinápticas de neuronas talamocorticales y su función en la generación de oscilaciones fisiológicas y patológicas
Las propiedades de membrana de las neuronas talamocorticales combinadas con la arquitectura de conexiones sinápticas recíprocas del circuito talamocortical dan lugar a la actividad oscilatoria que subyace a la generación ...
Gain modulation of synaptic inputs by network state in auditory cortex in vivo
(Society for Neuroscience, 2015-02)
The cortical network recurrent circuitry generates spontaneous activity organized into Up (active) and Down (quiescent) states during slow-wave sleep or anesthesia. These different states of cortical activation gain modulate ...
Disruption of thalamocortical activity in schizophrenia models: relevance to antipsychotic drug action
(Cambridge University Press, 2013-11)
Non-competitive NMDA receptor antagonists are widely used as pharmacological models of schizophrenia due to their ability to evoke the symptoms of the illness. Likewise, serotonergic hallucinogens, acting on 5-HT2A receptors, ...
The reward-attention circuit model: nicotine's influence on attentional focus and consequences on attention deficit hyperactivity disorder
(Elsevier Science Bv, 2017-06-14)
In this work we investigate the influence that nicotine exerts on attention focusing, modeling the coupling of reward and thalamocortical circuits. Each neuron in the neural networks that replicate such circuits is described ...