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Expression of SMAD proteins, TGF-beta/activin signaling mediators, in human thyroid tissues
(Sociedade Brasileira de Endocrinologia e Metabologia, 2010)
OBJECTIVE: To investigate the expression of SMAD proteins in human thyroid tissues since the inactivation of TGF-β/activin signaling components is reported in several types of cancer. Phosphorylated SMAD 2 and SMAD3 ...
Amifostine does not prevent activation of TGF beta 1 but induces smad 7 activation in megakaryocytes irradiated in vivo
(Wiley-Blackwell, 2002-11-01)
Experiments were undertaken to assess the role of amifostine in the activation of latent TGFbeta1 and in the smad proteins cascade (smad 2/3, smad4, smad7), focusing on megakaryocytes, in the bone marrow irradiated in vivo. ...
Amifostine does not prevent activation of TGF beta 1 but induces smad 7 activation in megakaryocytes irradiated in vivo
(Wiley-Blackwell, 2002-11-01)
Experiments were undertaken to assess the role of amifostine in the activation of latent TGFbeta1 and in the smad proteins cascade (smad 2/3, smad4, smad7), focusing on megakaryocytes, in the bone marrow irradiated in vivo. ...
SMAD3 is essential for transforming growth factor-β1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytes
(2012)
Transforming growth factor-β1 (TGF-β1) stimulates the extracellular matrix degrading proteases expression and cell migration in order to enhance cancer cells malignancy. In the present study, we analysed the role of ...
The steroid receptor co-activator-1 (SRC-1) potentiates TGF-β/Smad signaling: role of p300/CBP
(Nature Publishing Group, 2005-01)
The three related 160-kDa proteins, SRC-1, TIF-2 and RAC-3, were initially identi•ed as factors interacting with nuclear receptors. They have also been reported to potentiate the activity of other transcription factors ...
Research Smad2 and Smad6 as predictors of overall survival in oral squamous cell carcinoma patients
(BIOMED CENTRAL LTD, 2010)
Background: To test if the expression of Smad1-8 mRNAs were predictive of survival in patients with oral squamous cell carcinoma (SCC). Patients and Methods: We analyzed, prospectively, the expression of Smad1-8, by means ...
Participation of the SMAD2/3 signalling pathway in the down regulation of megalin/LRP2 by transforming growth factor beta (TGF-ss1)
(2019)
Megalin/LRP2 is a receptor that plays important roles in the physiology of several organs, such as kidney, lung, intestine, and gallbladder and also in the physiology of the nervous system. Megalin expression is reduced ...
Smad7 Blocks Transforming Growth Factor-beta 1-Induced Gingival Fibroblast-Myofibroblast Transition via Inhibitory Regulation of Smad2 and Connective Tissue Growth Factor
(Amer Acad PeriodontologyChicagoEUA, 2011)
Extracellular matrix remodeling and TGF-β1/Smad signaling in diabetic colon mucosa
(Academic Press Ltd - Elsevier Science Ltd, 2017-12)
Diabetes is associated with metabolic and functional alterations in the gut. Using an experimental model of streptozotocin (STZ)-induced diabetes in rodents, we analyzed the extracellular matrix (ECM) and TGF-β/Smad signaling ...