Now showing items 1-10 of 1178
Steady-state target optimization designs for integrating real-time optimization and model predictive control
In industrial practice, the optimal steady-state operation of continuous-time processes is typically addressed by a control hierarchy involving various layers. Therein, the Real-Time Optimization (RTO) layer computes the ...
Genetic algorithm in chemistry.
(Soc Brasileira QuimicaSao PauloBrasil, 1999)
Advanced Modeling Reconciles Counterintuitive Decisions in Lead Optimization
(Elsevier Science London, 2017-06)
Lead optimization (LO) is essential to fulfill the efficacy and safety requirements of drug-based targeted therapy. The ease with which water may be locally removed from around the target protein crucially influences LO ...
Therapeutic targets in chagas disease
Optimal pharmacotherapy occurs when we have selectivity and no toxicity. The discovery of specific pathways or enzymes that are vital forcell or parasite survival is also vital for the design of new specific, non-toxic ...
Optimal Takeover Contests with Toeholds
This paper characterizes how a target rm should be sold when raiders have prior stakes in its ownership (toeholds). We nd that the optimal mechanism needs to be implemented by a non-standard auction which imposes a ...
Probability-Based Design of Experiments for Batch Process Optimization with End-Point Specifications
(American Chemical Society, 2016-01)
Consistently complying with end-point specifications, mainly end-use product properties, is a key issue to thecompetitiveness of batch processes. To maximize in some way the probability of observing successful runs, a ...
Stable Model Predictive Control for Integrating Systems with Optimizing Targets
(AMER CHEMICAL SOC, 2009)
This paper concern the development of a stable model predictive controller (MPC) to be integrated with real time optimization (RTO) in the control structure of a process system with stable and integrating outputs. The real ...
Optimal management scenarios for the artisanal fisheries in the ecosystem of La Paz Bay, Baja California Sur, Mexico
(Ecological Modelling, 2004)
In La Paz Bay, two artisanal fisheries operate, one based on hook-and-line, targeting snappers and groupers, and the other mainly based on gillnets, targeting species such as tilefish and haemulids. A shrimp fishery, which ...