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Tissue pathology induced by snake venoms: How to understand a complex pattern of alterations from a systems biology perspective?
(2010-01)
The study of snake venom-induced local tissue pathology has been predominantly based on experimental designs and concepts that view tissue alterations from a dichotomous, homogeneous and reductionist perspective. Experimental ...
A biocomputational platform for the automated construction of large-scale mathematical models of miRNA-transcription factor networks for studies on gene dosage compensation
(2016-11-09)
Cancer complexity and resistance is mediated by
cell-to-cell heterogeneity, which is the consequence of the
enormous instability of its genetic material. It is unknown how
cancer cells are able to withstand the effects ...
Computational Biology in Costa Rica: the role of a small country in the global context of bioinformatics
(2008)
Introduction: The successful development of high throughput methods for DNA sequencing, transcriptomics, proteomics, and other –omics, has contributed to the emergence of novel possibilities for the examination of complex ...
Seasonal changes of the microplankton community along a tropical estuary
(2015-11)
Microplankton organisms are an important link in the transfer of matter and energy between the benthic–pelagic microbial food web and higher trophic levels in estuaries. Although tropical estuaries are among the most ...
Purification of equine whole IgG snake antivenom by using an aqueous two phase system as a primary purification step
(2015-01)
There is a need to introduce innovations in the manufacture of snake antivenoms to increase the supply of these products worldwide. In this work, the fractionation of equine hyperimmune plasma with a new methodology that ...
Utilización del nematodo entomopatógeno Heterorhabditis atacamensis CIA-NE07 en el control del picudo del banano cosmopolites sordidus en condiciones in vitro
(2015)
Entre las especies de barrenadores del banano, el picudo negro (Cosmopolites sordidus) es la plaga de mayor importancia económica en Costa Rica y a nivel mundial. El control de C. sordidus en sistemas intensivos de producción ...
Design of an optimized biomixture for the degradation of carbofuran based on pesticide removal and toxicity reduction of the matrix
(2015-12)
Pesticide biopurification systems contain a biologically active matrix (biomixture) responsible for the accelerated elimination of pesticides in wastewaters derived from pest control in crop fields. Biomixtures have been ...
Fungal bioaugmentation of two rice husk-based biomixtures for the removal of carbofuran in on-farm biopurification systems
(2016-02)
The ligninolytic fungus Trametes versicolor was employed in the bioaugmentation of compost- (GCS) and
peat-based (GTS) biomixtures for the removal of the insecticide-nematicide carbofuran (CFN). Among several lignocellulosic ...
Zika Virus (ZIKV): A New Emerging Pathogen Transmitted by Aedes Mosquitoes (Diptera: Culicidae) in the Latin American Subcontinent
(2016-03-11)
Aedes aegypti and Aedes albopictus (Diptera: Culicidae) are two
species of synanthropic mosquitoes that are common in outdoor
and indoor domiciliary environments in tropical countries. Their
vectorial competence and ...
Early behavioral changes after nigro-striatal system damage can serve as predictors of striatal dopamine depletion
(1999)
1. Rats which had received a unilateral injection of 6-OHDA into the substantia nigra were assigned to four lesion groups according to the degree of DA depletion in the neostriatum. In these animals, behavioral changes in ...