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α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies
(Nature Publishing Group, 2018-08)
Aggregation of α-synuclein, the hallmark of α-synucleinopathies such as Parkinson´s disease, occurs in various glycosphingolipidoses. Although α-synuclein aggregation correlates with deficiencies in the lysosomal degradation ...
Orthostatic hypotension and REM sleep behaviour disorder: Impact on clinical outcomes in α-synucleinopathies
(BMJ Publishing Group, 2019)
Objective: Review the effect of orthostatic hypotension (OH) and rapid-eye-movement sleep behavioural disorder (RBD) on survival, cognitive impairment and postural stability, and discuss pathogenic mechanisms involved in ...
Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson's disease
(Frontiers Media S.A., 2015)
Pontine calcification in late stage cerebellar multiple system atrophy: a marker of synucleinopathy neurodegeneration?
(Assoc Arquivos Neuro- Psiquiatria, 2017)
α-Synuclein and lipid metabolism: intersecting pathways
(Tech Science Press, 2019)
α-synuclein (α-syn) aggregation and fibrillation is a hallmark of a class of neurodegenerative disorders known as synucleinopathies. An intriguing and not completely clarified feature of α-syn is the many ways in which it ...
Peripheral inflammation regulates CNS immune surveillance through the recruitment of inflammatory monocytes upon systemic α-synuclein administration
(Frontiers Media S.A., 2019-01)
Innate immune activation and chronic neuroinflammation are characteristic features of many neurodegenerative diseases including Parkinson´s disease (PD) and may contribute to the pathophysiology of the disease. The discovery ...
Droxidopa for the treatment of neurogenic orthostatic hypotension in neurodegenerative diseases
(Taylor & Francis, 2019-02)
Introduction: L-threo-3,4-dihydroxyphenylserine (droxidopa), a pro-drug metabolized to norepinephrine in nerve endings and other tissues, has been commercially available in Japan since 1989 for treating orthostatic hypotension ...
Bioinorganic chemistry of synucleinopathies: Deciphering the binding features of Met motifs and His-50 in AS-Cu(I) interactions
(Elsevier Science Inc, 2014-12)
The aggregation of alpha-synuclein (AS) is a critical step in the etiology of Parkinson's disease (PD) and other neurodegenerative synucleinopathies. This process is selectively enhanced by copper in vitro and the interaction ...
Amyloid oligomerization of the Parkinson's disease related protein α-synuclein impacts on its curvature-membrane sensitivity
(Wiley Blackwell Publishing, Inc, 2018-11)
The amyloid aggregation of the presynaptic protein α-synuclein (AS) is pathognomonic of Parkinson's disease and other neurodegenerative disorders. Physiologically, AS contributes to synaptic homeostasis by participating ...
Neuronal inclusions of alpha-synuclein contribute to the pathogenesis of Krabbe disease
(Wiley, 2014-01)
Demyelination is a major contributor to the general decay of neural functions in children with Krabbe disease. However, recent reports have indicated a significant involvement of neurons and axons in the neuropathology of ...