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Evaluation of the performance of an ophthalmic thermosensitive hydrogel containing combination of suramin and bevacizumab
(Bentham Science Publishers, 2016-12)
Suramab (SUM) is a new pharmaceutical combination made up of suramine (SUR) and bevacizumab (BVM), which showed a high synergistic effect when administered jointly. As the pharmaceutical vehicle, poloxamer aqueous dispersions ...
Corneal neovascularization: a combined approach of bevacizumab and suramin showed increased antiangiogenic effect through downregulation of BFGF and P2X2
(Taylor & Francis, 2017-12)
Purpose: the objective is to analyze the antiangiogenic mechanism of suramab, a pharmaceutical compound of bevacizumab and suramin, in a rabbit model of corneal angiogenesis. Material and methods: corneal neovascularization ...
In vitro characterization of new stabilizing albumin nanoparticles as a potential topical drug delivery system in the treatment of corneal neovascularization (CNV)
(Editions Sante, 2019-08)
The aim of this work was to study the preparation process and the in vitro release of human serum albumin nanoparticles stabilized by Gantrez® ES-425, which was loaded with antiangiogenic drugs (suramin and bevacizumab). ...
Effects of islet neogenesis associated protein depend on vascular endothelial growth factor gene expression modulated by hypoxia-inducible factor 1-alpha
(Elsevier Science Inc, 2019-07)
Background Pharmacology has provided efficient tools to improve insulin effect/secretion but the decrease in β-cell mass remains elusive. INGAP-PP could provide a therapeutic alternative to meet that challenge. Aim To ...
Peritubular fluid viscosity modulates H + flux in proximal tubules through NO release
(American Physiological Society, 2001-02)
We evaluated the effects of increasing the viscosity (eta) in peritubular capillary perfusates (PCP; 20 mM HNaPO4--Ringer, pH 7.4) on proximal convoluted tubule (PCT) acidification. Micropuncture experiments were performed ...
Ca2+ signaling in injured in situ endothelium of rat aorta
(Elsevier, 2008-09)
The inner wall of excised rat aorta was scraped by a microelectrode and Ca2+ signals were investigated by fluorescence microscopy in endothelial cells (ECs) directly coupled with injured cells. The injury caused an immediate ...
Presynaptic inhibition of spontaneous acetylcholine release mediated by P2Y receptors at the mouse neuromuscular junction
(Pergamon-Elsevier Science Ltd, 2006-09)
At the neuromuscular junction, ATP is co-released with the neurotransmitter acetylcholine (ACh) and once in the synaptic space, it is degraded to the presynaptically active metabolite adenosine. Intracellular recordings ...