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Inhibition of Myotoxic Activity of Bothrops asper Myotoxin II by the Anti-trypanosomal Drug Suramin
(2005-06-15)
Suramin, a synthetic polysulfonated compound, developed initially for the treatment of African trypanosomiasis and onchocerciasis, is currently used for the treatment of several medically relevant disorders. Suramin, ...
Inhibition of Myotoxic Activity of Bothrops asper Myotoxin II by the Anti-trypanosomal Drug Suramin
(2005-06-15)
Suramin, a synthetic polysulfonated compound, developed initially for the treatment of African trypanosomiasis and onchocerciasis, is currently used for the treatment of several medically relevant disorders. Suramin, ...
Structural and thermodynamic analysis of thrombin:suramin interaction in solution and crystal phases
(ELSEVIER SCIENCE BV, 2009)
Suramin is a hexasulfonated naphthylurea which has been recently characterized as a non-competitive inhibitor of human alpha-thrombin activity over fibrinogen, although its binding site and mode of interaction with the ...
Mapping of suramin binding sites on the group IIA human secreted phospholipase A(2)
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009)
Suramin is a polysulphonated napthylurea used as an antiprotozoal/anthelminitic drug, which also inhibits a broad range of enzymes. Suramin binding to recombinant human secreted group IIA phospholipase A(2) (hsPLA(2)GIIA) ...
Inhibition of myotoxic activity of Bothrops asper myotoxin II by the anti-trypanosomal drug surarnin
(Elsevier B.V., 2005-07-15)
Suramin, a synthetic polysulfonated compound, developed initially for the treatment of African trypanosomiasis and onchocerciasis, is currently used for the treatment of several medically relevant disorders. Suramin, ...
Inhibition of myotoxic activity of Bothrops asper myotoxin II by the anti-trypanosomal drug surarnin
(Elsevier B.V., 2005-07-15)
Suramin, a synthetic polysulfonated compound, developed initially for the treatment of African trypanosomiasis and onchocerciasis, is currently used for the treatment of several medically relevant disorders. Suramin, ...
The repurposed drugs suramin and quinacrine cooperatively inhibit sars-cov-2 3clpro in vitro
(2021-01-01)
Since the first report of a new pneumonia disease in December 2019 (Wuhan, China) the WHO reported more than 148 million confirmed cases and 3.1 million losses globally up to now. The causative agent of COVID-19 (SARS-CoV-2) ...
Suramin inhibits respiration and induces membrane permeability transition in isolated rat liver mitochondria
(Elsevier Sci Ireland LtdClareIrlanda, 2001)
Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA2 from Bothrops asper venom
(2004-12-01)
Suramin is a highly charged polysulfonated napthylurea that interferes in a number of physiologically relevant processes such as myotoxicity, blood coagulation and several kinds of cancers. This synthetic compound was ...