Objective: Hyperechogenicity of the substantia nigra is a frequent observation on transcranial sonography in Parkinson's disease and Machado-Joseph disease patients. Additionally, restless legs syndrome is a sleep disorder ...

Angiotensin receptor II mRNA was found to be expressed in dopaminergic neuronal cell line RCSN3 of rat substantia nigra using RT-PCR reaction. Aminochrome (150 μM), a metabolite of the dopamine oxidative pathway, was found ...

Dopaminergic neurons (DANs) of the substantia nigra pars compacta (SNc) play a critical role in motor control, reward mechanisms, and learning. Dopamine release in the striatum, as well as in other brain regions, is tightly ...

In most dopaminergic neurons of the substantia nigra compacta (SNc), it has been described that the axon emerges from a primary or secondary dendrite. The axonal region most proximal to the soma is the axon initial segment ...

opaminergic neurons of the substantia nigra compacta (SNc) play a key role in movement control, motivated behavior and learning. The electrical activity of dopaminergic neurons is characterized by low frequency, regular ...

The axon initial segment (AIS) is the site of initiation of action potentials and influences action potential waveform, firing pattern, and rate. In view of the fundamental aspects of motor function and behavior that depend ...

Presentamos nuevos conceptos relativos a la etiología de la Enfermedad de Parkinson (EP). Basado en los hallazgos sobre la angio-arquitectura, relaciones neurona-vasculares y actividad metabólica de la zona compacta de la ...