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Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis

Busch, Lucila; Miozza, Valeria Alejandra; Sterin, Leonor Josefina; Borda, Enri Santiago (Springer, 2009-04)

Objective and design: In the present study, we investigated the relation between the inflammatory mediators such as nitric oxide, prostaglandins, and cysteinyl-leukotrienes with mucin release and the sympathetic system in ...

Larrea divaricata Cav. aqueous extract and nordihydroguariaretic acid modulate oxidative stress in submandibular glands of diabetic rats: A buccal protective in diabetes

Peralta, Ignacio Nahuel; Marrassini, Carla; Barreiro Arcos, María Laura; Cremaschi, Graciela Alicia; Alonso, María Rosario; Anesini, Claudia Alejandra (BioMed Central, 2019-08)

Background: Oxidative stress is an imbalance between the levels of reactive oxygen species (ROS), reactive nitrogen species (RNS) and endogenous antioxidants. The aetiology and pathogenesis of several oral diseases are ...

Pharmacological targeting of histamine H4 receptor in periodontal disease

Prestifilippo, Juan Pablo; Fernández Solari, José Javier; Martinel Lamas, Diego José; Rios, Carlos Ezequiel; Mohn, Claudia Ester; Perazzo, Juan C.; Rivera, Elena Susana; Elverdín, Juan Carlos; Medina, Vanina Araceli (Wiley Blackwell Publishing, Inc, 2016-02)

Objective: The objective of this study was to investigate whether histamine H4 receptor (H4R) antagonists could prevent experimental periodontitis (EP)-induced histological, functional and inflammatory alterations in ...

Lack of nitric oxide-mediated regulation of amylase secretion stimulated by VIP in parotid glands of NOD mice

Roca, Valeria Ines; Rosignoli, Florencia; Calafat, Mario Jose; Perez Leiros, Claudia (Elsevier Science, 2004-12)

The non-obese diabetic (NOD) mouse is chosen among other experimental models to study autoimmune sialadenitis resembling Sjögren's syndrome (SS), because of its unique characteristic of developing salivary dysfunction. ...

Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis

Rosignoli, F.; Roca, Valeria Ines; Meiss, R.; Leceta, J.; Gomariz, Roberto Luis; Perez Leiros, Claudia (Wiley Blackwell Publishing, Inc, 2005-12)

The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse ...

Chronic Alcohol Consumption Alters Periodontal Health in Rats

Surkin, Pablo Nicolas; Ossola, Cesar Angel; Mohn, Claudia Ester; Elverdín, Juan Carlos; Fernández Solari, José Javier (Wiley, 2014-06)

BACKGROUND: The aim of this study was to assess the effects of chronic alcohol consumption on periodontitis development in rats. METHODS: Periodontal disease was experimentally induced by lipopolysaccharide (LPS; 2 mg/ml) ...