Now showing items 1-10 of 3548
Structural antitumoral activity relationships of synthetic chalcones
Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2'-hydroxychalcones resulted in apoptosis induction ...
Structure-activity relationship of mastoparan analogs: effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity
(Elsevier B. V., 2015-05-02)
In this study, a series of mastoparan analogs were engineered based on the strategies of Ala and Lys scanning in relation to the sequences of classical mastoparans. Ten analog mastoparans, presenting from zero to six Lys ...
Synthesis, leishmanicidal activity, structural descriptors and structure-activity relationship of quinoline derivatives
(Future Sci Ltd, 2018-09-01)
Aim: Considering the epidemiology of leishmaniasis, the emergence of resistant parasites to the approved drugs, and severe clinical manifestations, the development of novel leishmanicidal molecules has become of considerable ...
Structure-antioxidant activity relationships of flavonoids isolated from the resinous exudate of Heliotropium sinuatum
(Pergamon-Elsevier Science Ltd., 2005)
The correlation between electronic structure and antimalarial activity of tetrahydropyridines
(Soc Brasileira Quimica, 2015-02-01)
In this study, correlations between electronic structure and the antimalarial activities reported for a group of 21 tetrahydropyridines were evaluated by multivariate methods. Simple and multiple linear regressions, principal ...
Quantum-Chemical Structure-Activity Relationships in Carbamate Insecticides
(Kluwer Academic Publishers, 1995-01-10)
A non-empirical Quantitative Structure-Activity Relationship (QSAR) method is employed to analyze the reversible complex formation during the reaction of phenyl-N-methylcarbamates with the enzyme acetylcholinesterase. ...
A structure-activity relationship study of quinone compounds with trypanocidal activity
(Elsevier B.V., 2005-04-01)
A set of 25 quinone compounds with anti-trypanocidal activity was studied by using the density functional theory (DFT) method in order to calculate atomic and molecular properties to be correlated with the biological ...
Toxicity caused by para-substituted phenols on Tetrahymena pyriformis: The structure-activity relationships
(Pontificia Universidad Católica de Valparaíso, 2008)
Chagas disease pharmacotherapy and its chemical structure activity relationship
Therapeutic arsenal currently available for Chagas disease is restricted in only two drugs, nifurtimox and benznidazole, since 1960s and 1970s, respectively. Despite the efforts to develop new drugs, until now, no new drugs ...