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Retamycin production by immobilized cells of Streptomyces olindensis ICB20 in repeated-batch cultures

PINHEIRO, Iara Reboucas; FACCIOTTI, Maria Candida Reginato (ELSEVIER SCI LTD, 2008)

Repeated-batch cultures of Ca-alginate immobilized cells of Streptomyces olindensis ICB20 for retamycin production were carried out in two different bioreactors: a basket-type stirred tank reactor (BSTR) and a bubble column ...

Metabolic flux analysis for directing metabolism of Streptomyces olindensis from growth to anti-tumor drug (cosmomycin) production

Carvalho Lima Lobato, Ana de; Munoz-Hernandez, Raul ; Furlan, Renata ; Padilla, Gabriel ; Garrido, Leandro M; Macedo, Gorete de; Mavituna, Ferda (2007)

Characterisation of anthracyclines from a cosmomycin D-producing species of Streptomyces by collisionally-activated dissociation and ion mobility mass spectrometry

KELSO, Celine; ROJAS, Juan Diego; FURLAN, Renata L. A.; PADILLA, Gabriel; BECK, Jennifer L. (IM PUBLICATIONS, 2009)

Cultures of cosmomycin D-producing Streptomyces olindensis ICB20 that were propagated for many generations underwent mutations that resulted in production of a range of related anthracyclines by the bacteria. The anthracyclines ...

DNA damage induced by the anthracycline cosmomycin D in DNA repair-deficient cells

CARVALHO, Helotonio; GARRIDO, Leandro M.; FURLAN, Renata L. A.; PADILLA, Gabriel; AGNOLETTO, Mateus; GUECHEVA, Temenouga; HENRIQUES, Joao A. P.; SAFFI, Jenifer; MENCK, Carlos Frederico Martins (SPRINGER, 2010)

Anthracyclines have been widely used as antitumor agents, playing a crucial role in the successful treatment of many types of cancer, despite some side effects related to cardiotoxicity. New anthracyclines have been designed ...