Now showing items 1-10 of 595
Sinergystic effects of steroidal glycosides of Solanum upon Human A375 Melanoma cells. A comparison with 1 Ketoconazole
(Facultad Experimental de Ciencias de la Universidad del Zulia, 2017)
Steroid diversification by multicomponent reactions
Reports on structural diversification of steroids by means of multicomponent reactions (MCRs) have significantly increased over the last decade. This review covers the most relevant strategies dealing with the use of ...
Structure-activity relationships of neuroactive steroids acting on the GABAA receptor
(Bentham Science Publishers, 2009-12)
The term "neuroactive steroid" (NAS) refers to steroids which, independent of their origin, are capable of modifying neural activities. These steroids positively or negatively modulate the function of members of the ...
Reconstitution of the steroid receptor heterocomplex
(Humana Press, 2019-03)
Steroid receptors are members of a subfamily of the nuclear receptor superfamily. They play a dual role of steroid hormone receptors and transcription factors. Actually, these receptors are steroid-activated transcription ...
Use of enhancement drugs amongst athletes and television celebrities and public interest in androgenic anabolic steroids. Exploring two Peruvian cases with Google Trends
Non-medical use of anabolic-androgenic steroids (AAS) has been reported in non-competitive athletes with the intention to improve physical appearance, particularly muscle size and definition. The misuse of AASdnamely, ...
Model systems for the study of steroid-induced IOP elevation
(Academic Press Ltd - Elsevier Science Ltd, 2017-05)
Steroid-induced IOP elevation affects a significant number of patients. It results from a decrease in outflow facility of the aqueous humor. To understand the pathophysiology of this condition a number of model systems ...
Plant and animal steroids a new hope to search for antiviral agents
(Bentham Science Publishers, 2010-01)
Scientific literature provides evidence about the use of steroids as an adjunct treatment to antiviral therapies. Immunomodulatory activity of some steroids would account for the recovery in patients with herpetic and other ...
Developmental programming of the female neuroendocrine system by steroids
(Wiley Blackwell Publishing, Inc, 2018-10)
Developmental programming refers to processes that occur during early life that may have long-term consequences, modulating adult health and disease. Complex diseases, such as diabetes, cancer and cardiovascular disease, ...
Highly stereoselective synthesis of steroidal 2,5-diketopiperazines based on isocyanide chemistry
(Pergamon-Elsevier Science Ltd, 2009-07)
In this Letter we report that the Ugi reaction/cyclization sequence on a steroidal 17-carboxaldehyde leads to novel steroidal 2,5-diketopiperazines with a noteworthy stereoselectivity. A wide variety in the substitution ...
Synthesis of C-C bonded dimeric steroids by olefin metathesis
(Pergamon-Elsevier Science Ltd, 2009-05)
Five new C-C bonded steroidal homodimers derived from deoxycholic acid, pregnenolone, and progesterone were synthesized by an olefin metathesis reaction assisted by microwave heating. Microwave improved the yield and ...