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Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail
(Shanghai Institute of Materia Medica, 2012-01)
This article presents an update on the variable prognostic significance of different sperm pathologies in patients with severe male factor infertility due to morphology and motility disorders. Severe asthenozoospermia is ...
Laboratory evaluation of sperm-ovum interaction
(Elsevier Inc, 2018)
The article will briefly address background information on relevant events involved in sperm–ovum interaction leading to fertilization. Reference to published work and laboratory protocols will be presented for the following ...
Murine sperm capacitation, oocyte penetration and decondensation following moderate alcohol intake
(BioScientifica, 2018-12)
Male chronic alcohol abuse causes testicular failure and infertility. We analyzed the effects of moderate sub-chronic alcohol intake on sperm morphology, capacitation, fertilization and sperm head decondensation. CF-1 male ...
The making of abnormal spermatozoa: Cellular and molecular mechanisms underlying pathological spermiogenesis
(Springer, 2010-09)
Fertilization in mammals occurs via a series of well-defined events in the secluded environment of the female reproductive tract. The mode of selection of the fertilizing spermatozoon nevertheless remains unknown. As has ...
A TEM-traceable physiologically functional gold nanoprobe that permeates non-endocytic cells
(Dove Press, 2018-11)
Background: Nanoparticles’ intracellular fate requires proper internalization. Most cells make use of a battery of internalization pathways, but some are practically sealed, as they lack the biochemical machinery for ...
Identification of human sperm proteins involved in the interaction with homologous zona pellucida
(American Society for Reproductive Medicine, 2003-06)
To identify human sperm proteins involved in homologous zona pellucida (ZP) interaction.Fertilization results from successful interaction between the female and male gametes. Capacitated human spermatozoa initially bind, ...
Human testicular protein TPX-1/CRISP-2: localization in spermatozoa, fate after capacitation and relevance for gamete interaction
(Oxford University Press, 2005)
Testicular protein Tpx-1, also known as CRISP-2, is a cysteine-rich secretory protein specifically expressed in the male reproductive tract. Since the information available on the human protein is limited to the identification ...
Capacitation-induced mitochondrial activity Is required for sperm fertilizing ability in mice by modulating hyperactivation
(Frontiers Media, 2021-10)
To become fully competent to fertilize an egg, mammalian sperm undergo a series of functional changes within the female tract, known as capacitation, that require an adequate supply and management of energy. However, the ...
Evaluation of testicular sperm CRISP2 as a potential target for contraception
(American Society of Andrology, 2012-11-12)
Cysteine-rich secretory protein 2 (CRISP2) is a testicular sperm protein proposed to be involved in fertilization. With the aim of examining the relevance of CRISP2 for fertility and its potential use as a target for ...