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Peptide synthesis: chemical or enzymatic
(Pontificia Universidad Católica de Valparaíso, 2007)
Solid-phase peptide synthesis in highly loaded conditions
(Academic Press Inc. Elsevier B.V., 2011-02-01)
The use of very highly substituted resins has been avoided for peptide synthesis due to the aggravation of chain-chain interactions within beads. To better evaluate this problem, a combined solvation-peptide synthesis ...
Solid-phase peptide synthesis in highly loaded conditions
(Academic Press Inc. Elsevier B.V., 2011-02-01)
The use of very highly substituted resins has been avoided for peptide synthesis due to the aggravation of chain-chain interactions within beads. To better evaluate this problem, a combined solvation-peptide synthesis ...
Comparative investigation of the cleavage step in the synthesis of model peptide resins: Implications for N-alpha-9-fluorenylmethyloxycarbonyl-solid phase peptide synthesis
(Pharmaceutical Soc Japan, 2007-03-01)
Based on our studies of the stability of model peptide-resin linkage in acid media, we previously proposed a rule for resin selection and a final cleavage protocol applicable to the N-alpha-tert-butyloxycarbonyl (Boc)-peptide ...
Solid-phase peptide synthesis at elevated temperatures: a search for an optimized synthesis condition of unsulfated cholecystokinin-12
(Munksgaard Int Publ Ltd, 1997-08-01)
A systematic investigation of solid-phase peptide synthesis at elevated temperatures using the well-known aggregating peptide acyl carrier protein (65-74) and the unsulfated cholecystokinin-8 as models is presented. The ...
Regioselective Incorporation of Backbone Constraints Compatible with Traditional Solid-Phase Peptide Synthesis
(American Chemical Society, 2012-12)
A protected aldehyde was attached via a twocarbon spacer to a peptide backbone amide nitrogen during a traditional Merrifield solid-phase synthesis. Acid-mediated unmasking of the aldehyde triggered the regioselective ...
Ca(2+)-mediated thiolysis of peptide-resin linkage as an option for preparing protected peptide thioesters
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
A mild new procedure for preparing protected peptide thioesters, based oil Ca(2+)-assisted thiolysis of peptide-Kaiser oxime resin (KOR) linkage, is described. Ac-Ile-Ser(Bzl)-Asp(OcHx)-SR (Ac: acetyl; Bzl: benzyl; cHx: ...
Study of the effect of the peptide loading and solvent system in SPPS by HRMAS-NMR
(Wiley-Blackwell, 2005-09-01)
The SPPS methodology has continuously been investigated as a valuable model to monitor the solvation properties of polymeric materials. In this connection, the present work applied HRMAS-NMR spectroscopy to examine the ...
Study of the effect of the peptide loading and solvent system in SPPS by HRMAS-NMR
(Wiley-Blackwell, 2005-09-01)
The SPPS methodology has continuously been investigated as a valuable model to monitor the solvation properties of polymeric materials. In this connection, the present work applied HRMAS-NMR spectroscopy to examine the ...