Now showing items 1-10 of 2165
Dissolution Enhancement and Characterization of Nimodipine Solid Dispersions with Poloxamer 407 or PEG 6000
(TAYLOR & FRANCIS INCPHILADELPHIA, 2012)
The solid dispersion approach is an alternative to increase drug solubility. Many carriers have been studied, but there is few information about poloxamer 407 (P407). Consequently, the objective of this study was to evaluate ...
Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus®
(Universidade Federal do Rio Grande do NorteBrasilUFRNFarmácia, 2020-06-18)
Development and in vitro evaluation of solid dispersions as strategy to improve albendazole biopharmaceutical behavior
(Future Medicine Ltd., 2018-09)
Solid dispersions using Poloxamer 407 as carrier were developed to improvealbendazole (ABZ) solubility and dissolution profiles. ABZ/poloxamer solid dispersions were prepared, and dissolution profiles were mathematically ...
Unexpected Performance of Physical Mixtures over Solid Dispersions on the Dissolution Behavior of Benznidazole from Tablets
This work investigated the feasibility of developing benznidazole (BZL) tablets, allowing fast, reproducible, and complete drug dissolution, by compressing BZL-Polyethylene Glycol (PEG) 6000 physical mixtures (PMs) and ...
Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel
The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid Dispersion (SD) has tremendous potential for improving drug solubility. Although praziquantel (PZQ) is the first ...
Third-generation solid dispersion combining Soluplus and poloxamer 407 enhances the oral bioavailability of resveratrol
(Elsevier B.V., 2021-02-15)
Resveratrol is a very promising anti-oxidant drug candidate with low oral bioavailability due to its intrinsic poor water solubility, intestinal efflux and metabolization mechanisms. Resveratrol solubility high-throughput ...
Improving the dissolution of Triclabendazole from stable crystalline solid dispersions formulated for oral delivery
Triclabendazole belongs to the class II/IV of the Biopharmaceuticals Classification System, and its low aqueous solubility represents a major drawback during the development of effective dosage forms. Therefore, the goal ...
Development and physicochemical characterization of solid dispersions containing praziquantel for the treatment of schistosomiasis
Praziquantel (PZQ) is an anthelminthic agent active against parasitic flatworms of the Schistosoma type and the most important drug for the treatment and morbidity control of schistosomiasis. In this study, a high-performance ...