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Impact of Regional Variation in Bothrops asper Snake Venom on the Design of Antivenoms: Integrating Antivenomics and Neutralization Approaches
(2010-10-21)
Intraspecific snake venom variations have implications in the preparation of venom pools for the generation of antivenoms. The impact of such variation in the cross-reactivity of antivenoms against Bothrops asper venom was ...
Venom, venomics, antivenomics
(2009)
Venoms comprise mixtures of peptides and proteins tailored by Natural Selection to act on vital systems
of the prey or victim. Here we review our proteomic protocols for uncoiling the composition,
immunological profile, ...
Feeding behavior and venom toxicity of coral snake Micrurus nigrocinctus (Serpentes: Elapidae) on its natural prey in captivity
(2004-08)
The feeding behavior and venom toxicity of the coral snake Micrurus nigrocinctus (Serpentes: Elapidae) on its natural prey in captivity were investigated. Coral snakes searched for their prey (the colubrid snake Geophis ...
New insights into the phylogeographic distribution of the 3FTx/PLA2 venom dichotomy across genus Micrurus in South America
(2019)
Micrurus is a monophyletic genus of venomous coral snakes of the family Elapidae. The ~80 recognized species
within this genus are endemic to the Americas, and are distributed from southeastern United States to ...
Experimental myonecrosis induced by the venoms of South American Micrurus (coral snakes)
(1992)
Venoms from 11 taxa of Micrurus (coral snakes) from Brazil and Colombia were tested for myotoxic activity in mice. All venoms, except that of M. surinamensis, induced myotoxicity as judged by the increase in plasma creatine ...
Venomous snakes of Costa Rica: biological and medical implications of their venom proteomic profiles analyzed through the strategy of snake venomics
(Journal of Proteomics XX (2014) XXX – XXX, Available online 24 February 2014, 2014-02-24)
In spite of its small territory of ~50,000 km2, Costa Rica harbors a remarkably rich biodiversity. Its herpetofauna includes 138 species of snakes, of which sixteen pit vipers (family Viperidae, subfamily Crotalinae), five ...
First insights into the venom composition of two Ecuadorian coral snakes
(2022)
Micrurus is a medically relevant genus of venomous snakes composed of 85 species. Bites caused by coral snakes are rare, but they are usually associated with very severe and life-threatening clinical manifestations. Ecuador ...
Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming
(2009-03-06)
Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact, particularly in Asia, Africa and Latin America. A global initiative, aimed at increasing antivenom production and ...
Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms
(2017-04)
This work offers a general overview on the evolving strategies for the proteomic analysis of snake venoms, and
discusses how these may be combined through diverse experimental approaches with the goal of achieving a
more ...
Venomic analysis of the poorly studied desert coral snake, Micrurus tschudii tschudii, supports the 3FTx/PLA2 dichotomy across Micrurus venoms
(2016)
The venom proteome of the poorly studied desert coral snake Micrurus tschudii tschudii
was unveiled using a venomic approach, which identified ¥38 proteins belonging to only four snake
venom protein families. The ...