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Recent advances in siRNA delivery mediated by lipid-based nanoparticles
Small interfering RNA (siRNA) has been expected to be a unique pharmaceutic for
the treatment of broad-spectrum intractable diseases. However, its unfavorable properties
such as easy degradation in the blood and ...
Polymeric Systems as Nanodevices for siRNA Delivery
(Bentham Science Publ Ltd, 2013-10-01)
The delivery of small interfering RNAs (siRNAs) is a promising approach to silencing gene expression aimed at treating infections, cancer, neurodegenerative diseases and various other disorders. Recent progress in this ...
Polymeric systems as nanodevices for siRNA delivery
(2013-12-25)
The delivery of small interfering RNAs (siRNAs) is a promising approach to silencing gene expression aimed at treating infections, cancer, neurodegenerative diseases and various other disorders. Recent progress in this ...
Inhibition of hepatitis C virus using siRNA targeted to the virus and Hsp90
(2017-01-01)
Hepatitis C (HCV) is a viral disease affecting millions of people worldwide, and persistent HCV infection can lead to progressive liver disease with the development of liver cirrhosis and hepatocellular carcinoma. During ...
Use of small interfering RNA (siRNA) as a viral replication inhibitor of Human Herpesvirus 1 in BALB/C mice with keratoconjuntivitis
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2018)
Diethylaminoethyl- chitosan as an efficient carrier for siRNA delivery: Improving the condensation process and the nanoparticles properties
(2018-11-01)
Chitosan has been indicated as a promising carrier for the preparation of small interfering RNA (siRNA) delivery systems due to its remarkable properties. However, its weak interactions with siRNA molecules makes the ...
Inhibition of thimet oligopeptidase by siRNA alters specific intracellular peptides and potentiates isoproterenol signal transduction
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
Mammalian cells have a large number of intracellular peptides that are generated by extralysosomal proteases. In this study, the enzymatic activity of thimet oligopeptidase (EP24.15) was inhibited in human embryonic kidney ...
Double-grafted chitosans as siRNA nanocarriers: effects of diisopropylethylamine substitution and labile-PEG coating
(Springer, 2022-03-31)
The preparation of safe and efficient siRNA carriers remains a challenge that has limited the therapeutic applications of siRNA. In this study, the design of a new small interfering RNA (siRNA) carrier based on ...