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Initial steps in selenocysteine biosynthesis: The interaction between selenocysteine lyase and selenophosphate synthetase
(Elsevier B.V., 2020-08-01)
The selenocysteine (Sec) incorporation is a co-translational event taking place at an in-frame UGA-codon and dependent on an organized molecular machinery. Selenium delivery requires mainly two enzymes, the selenocysteine ...
Formation of a ternary complex for selenocysteine biosynthesis in bacteria
(The American Society for Biochemistry and Molecular Biology, 2015-09-16)
The synthesis of selenocysteine-containing proteins (selenoproteins) involves the interaction of Selenocysteine Synthase (SelA), tRNA (tRNASec), Selenophosphate Synthetase (SelD, SPS), a specific elongation factor (SelB) ...
Assembly stoichiometry of bacterial selenocysteine synthase and SelC (tRNAsec)
(Elsevier BVAmsterdam, 2013-04)
In bacteria selenocysteyl-tRNAsec (SelC) is synthesized by selenocysteine synthase (SelA). Here we show by fluorescence anisotropy binding assays and electron microscopical symmetry analysis that the SelA-tRNAsec binding ...
Genomic Characterization of Campylobacter jejuni Adapted to the Guinea Pig (Cavia porcellus) Host
(Frontiers Media, 2021)
Campylobacter jejuni is the leading bacterial cause of gastroenteritis worldwide with excessive incidence in low-and middle-income countries (LMIC). During a survey for C. jejuni from putative animal hosts in a town in the ...
Selenocysteine biosynthesis and insertion machinery in Naegleria gruberi
(Elsevier BVAmsterdam, 2013-04)
Selenium (Se) is an essential trace element primarily found in selenoproteins as the 21st amino acid (selenocysteine, Sec, or U). Selenoproteins play an important role in growth and proliferation and are typically involved ...
Selenocysteine incorporation in Kinetoplastid: Selenophosphate synthetase (SELD) from Leishmania major and Trypanosoma brucei
(ELSEVIER SCIENCE BV, 2008)
Selenophosphate synthetase (EC 2.7.9.3), the product of the selD gene, produces the biologically selenium donor compound, monoselenophosphate, from ATP and selenide, for the synthesis of cysteine. The kinetoplastid Leishmania ...
The Specific Elongation Factor to Selenocysteine Incorporation in Escherichia coli: Unique tRNASec Recognition and its Interactions
(2021-11-19)
Several molecular mechanisms are involved in the genetic code interpretation during translation, as codon degeneration for the incorporation of rare amino acids. One mechanism that stands out is selenocysteine (Sec), which ...
Formation of a ternary complex for selenocysteine biosynthesis in bacteria
(The American Society for Biochemistry and Molecular Biology, 2015)
Formation of a ternary complex for selenocysteine biosynthesis in bacteria
(The American Society for Biochemistry and Molecular Biology, 2015)
An efficient protocol for the production of tRNA-free recombinant Selenocysteine Synthase (SELA) from Escherichia coli and its biophysical characterization
(ElsevierAmsterdam, 2013-03)
Selenocysteine Synthase (SELA, E.C. 2.9.1.1) from Escherichia coli is a homodecamer pyridoxal-5′-phosphate containing enzyme responsible for the conversion of seryl-tRNA sec into selenocysteyl-tRNA sec in the biosynthesis ...