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Novel Alpha-Synuclein Oligomers Formed with the Aminochrome-Glutathione Conjugate Are Not Neurotoxic
(Springer New York LLC, 2019)
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.Aminochrome induces neurotoxic alpha-synuclein oligomer formation relevant to the etiology of Parkinson’s disease. Oxidative stress produces aminochrome ...
α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies
(Nature Publishing Group, 2018-08)
Aggregation of α-synuclein, the hallmark of α-synucleinopathies such as Parkinson´s disease, occurs in various glycosphingolipidoses. Although α-synuclein aggregation correlates with deficiencies in the lysosomal degradation ...
Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment
(Elsevier Science Inc, 2018-08)
α-synuclein is involved in both familial and sporadic Parkinson's disease. Although its interaction with mitochondria has been well documented, several aspects remains unknown or under debate such as the specific ...
Spinal cord stimulation improves forelimb use in an alpha-synuclein animal model of Parkinson’s disease
(Taylor and Francis Ltd, 2017)
Copyright © 2016 Informa UK Limited, trading as Taylor & Francis Group.Neuromodulation by spinal cord stimulation has been proposed as a symptomatic treatment for Parkinson’s disease. We tested the chronic effects of spinal ...
Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging
(Public Library of Science, 2015-04)
There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies. These disorders present with a variable extent of cognitive ...
Drp-1 dependent mitochondrial fragmentation and protective autophagy in dopaminergic SH-SY5Y cells overexpressing alpha-synuclein
(Academic Press Inc Elsevier Science, 2018-04)
Parkinson's disease is a neurodegenerative movement disorder caused by the loss of dopaminergic neurons from substantia nigra. It is characterized by the accumulation of aggregated α-synuclein as the major component of the ...
Structural Insights into Amyloid Oligomers of the Parkinson Disease-related Protein α-Synuclein
(American Society for Biochemistry and Molecular Biology, 2014-09)
The presence of intraneuronal deposits mainly formed by amyloid fibrils of the presynaptic protein α-synuclein (AS) is a hallmark of Parkinson disease. Currently, neurotoxicity is attributed to prefibrillar oligomeric ...
Features of alpha-synuclein that could explain the progression and irreversibility of parkinson´s disease.
(2015)
Alpha-synuclein is a presynaptic protein expressed throughout the central nervous system, and it is the main component of Lewy bodies, one of the histopathological features of Parkinson's disease (PD) which is a progressive ...