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Molecular properties of steroids involved in their effects on the biophysical state of membranes
(Elsevier Science, 2015-08)
The activity of steroids on membranes was studied in relation to their ordering, rigidifying, condensing and/or raft promoting ability. The structures of 82 steroids were modeled by a semi-empirical procedure (AM1) and 245 ...
Molecular chaperones shape steroid receptor action and pharmacologic strategies
(Jacobs Publisher, 2015-03-31)
Chaperone oligomers exist in cell cytosols as preassembled heterocomplexes that function as protein-folding molecular machines able to assemble essential proteins related to families that embrace steroid receptors, ...
Structure-activity relationship (SAR) studies of the tripos benchmark steroids
(Elsevier Science BvAmsterdamHolanda, 2002)
Predicting the effect of steroids on membrane biophysical properties based on the molecular structure
(Elsevier, 2012-03)
The relationship between sterol structure and the resulting effects on membrane physical properties is still unclear, owing to the conflicting results found in the current literature. This study presents a multivariate ...
Dereplication of extracts from nutraceutical mushrooms pleurotus using molecular network approach
(2022-02-15)
Pleurotus is an edible mushroom from the well-known genus of Basidiomycetes; it is the second-most commonly consumed mushroom worldwide. This genus is characterized by the presence of steroids, fatty acids, and polysaccharides. ...
QSAR of progestogens: Use of a priori and computed molecular descriptors and molecular graphics
(Wiley-v C H Verlag GmbhWeinheimAlemanha, 2003)
Solanocapsine derivatives as potential inhibitors of acetylcholinesterase: Synthesis, molecular docking and biological studies
(Elsevier Science Inc, 2015-09)
The investigation of natural products in medicinal chemistry is essential today. In this context, acetylcholinesterase (AChE) inhibitors comprise one type of the compounds most actively studied in the search for an effective ...
Light-responsive hybrid material based on luminescent core-shell quantum dots and steroidal organogel
(Royal Society of Chemistry, 2016-06)
We report the synthesis of a smart novel hybrid with reversible photoswitchable luminescence properties modulated by light. The combination of a low molecular weight organogelator (LMOG) and CdSe/ZnS core-shell semiconductor ...
Activation of the ligand-mineralocorticoid receptor functional unit by ancient, classical, and novel ligands: structure-activity relationship
(Elsevier Inc, 2004)
The mineralocorticoid effect on epithelial cells is the resultant of an intricate net of biochemical regulations that ultimately leads to the maintenance of electrolyte homeostasis. Two key protagonists in this plot are ...