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Synthesis of new cyano-substituted analogues of Tröger's bases from bromo-derivatives. A stereochemical dependence of long-range ( n J HH , n = 4, 5, and 6) proton-proton and proton-carbon ( n J CH , n = 1, 2, 3, 4, and 5) coupling constants of these compounds
(John Wiley & Sons Ltd, 2019-04)
A free-catalyst microwave-assisted cyanation of brominated Tröger´s base derivatives (2a-f) is reported. The procedure is simple, efficient and clean affording the nitrile compounds (3a-e, I) in very good yields. Complete ...
Molecular basis for the ph dependent structural transition of nitrophorin 4
(American Chemical Society, 2009-02)
Allostery can be defined in a broad sense as a structural change in a protein. The theoretical framework for allostery includes several formulations. In the stereochemical view, the activation event causes a local ...
Efficient synthesis of chiral Δ2-1,3,4-thiadiazolines from α-pinene and verbenone
(Pergamon-Elsevier Science Ltd, 2011-10)
The synthesis of chiral cyclobutane 1,3,4-thiadiazoline derivatives starting from (-)alfa pinene and (-)verbenone was studied. The diastereoisomeric excesses of the products obtained depended strongly upon the starting ...
Chiral auxiliary-mediated enantioenrichment of (±)-ibuprofen, under steglich conditions, with secondary alcohols derived from (R)-carvone
(Sociedade Brasileira de Química, 2010-03)
The synthesis of a series of chiral secondary alcohols derived from (R)-carvone, and the stereochemical outcome of their reaction with (±)-ibuprofen, is reported. The racemic drug was transformed into the corresponding ...
Redefiniendo el impacto del análisis conformacional por Boltzmann en la asignación estereoquímica de moléculas polares y flexibles mediante cálculos de RMN
(Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires", 2021-09)
Actualmente la Resonancia Magnética Nuclear constituye una de las herramientas más poderosas para la elucidación estructural de nuevas moléculas orgánicas complejas. A pesar de los enormes avances en la disciplina la ...