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Impairment of angiogenic sphingosine kinase-1/sphingosine-1-phosphate receptors pathway in preeclampsia
(2016)
Preeclampsia (PE), is a serious pregnancy disorder characterized in the early gestation by shallow trophoblast invasion, impaired placental neo-angiogenesis, placental hypoxia and ischemia, which leads to maternal and fetal ...
Sphingosine kinase signalling in immune cells
(SABER ULA, 2008)
Sphingosine kinase signalling in immune cells
(SABER ULA, 2008)
Optimized protocols to analyze sphingosine 1-phosphate signal transduction pathways during acrosomal exocytosis in human sperm
(Humana Press, 2012)
Regulated secretion is a central issue for the specific function of many cells; for instance, mammalian sperm acrosomal exocytosis is essential for egg fertilization. Sphingosine 1-phosphate is a bioactive sphingolipid ...
Identification of a sphingosine-sensitive Ca2+ channel in the plasma membrane of Leishmania mexicana
(Biochemical and Biophysical Research Communications, 2013)
Stratification of Sphingosine Kinase-1 Expression and Activity in Rat Kidney
(Karger, 2008-12)
Sphingosine-1-phosphate, the product of sphingosine kinase (SK) activity, is a sphingolipid metabolite that regulates cell growth, survival and migration. It is also known to affect diuresis, natriuresis and renovascular ...
Targeting defective sphingosine kinase 1 in Niemann–Pick type C disease with an activator mitigates cholesterol accumulation
(American Society for Biochemistry and Molecular Biology, 2020-07)
Niemann–Pick type C (NPC) disease is a lysosomal storage disorder arising from mutations in the cholesterol-trafficking protein NPC1 (95%) or NPC2 (5%). These mutations result in accumulation of low-density lipoprotein-derived ...
Quantification of sphingosine-1-phosphate (S1P) in patients with periodontitis stage II grade B
(Facultad de Odontología. Universidad de Costa Rica, 2022)
Sphingolipids as emerging mediators in retina degeneration
(Frontiers Media S.A., 2019-06-11)
The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions. Their roles in the retina have gained ...
Identification and electrophysiological properties of a sphingosine-dependent plasma membrane Ca2+ channel in Trypanosoma cruzi
(Wiley Blackwell Publishing, Inc, 2019-10)
Trypanosoma cruzi is the causative agent of Chagas disease. The only two drugs accepted for the treatment of this infection are benznidazole and nifurtimox, which are of limited use in the predominant chronic phase. On the ...