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Advances in metal-mediated solid-phase synthesis of heterocyclic compounds
(Springer, 2017)
While heterocycles are a key feature frequently found in compounds with pharmaceutical or agrochemical interest, the combination between solidsupported synthesis and organometallic chemistry has demonstrated to be a helpful ...
Palladium-Catalyzed Cross-Coupling Reactions of Arylsiloxanes with Aryl Halides: Application to Solid-Supported Organic Synthesis
(American Chemical Society, 2014-04)
The solid-phase version of the Pd-catalyzed Hiyama reaction between a variety of aryltriethoxysilanes and immobilized aryl halides was developed. Smooth crosscoupling was achieved to afford the corresponding biaryl ...
Synthesis of 3-aryl-1,2,4-benzotriazines via intramolecular cyclization of solid-supported o-hydrazidoanilines
(Springer, 2012-10)
An efficient solid-phase protocol for the rapid generation of libraries of biologically promising 1,2,4-benzotriazines, including amino acid-derived components, is described.
Recent advances in the solid-phase synthesis of N-heteroaromatic five membered rings
(Research Signpost, 2007)
Combinatorial chemistry and related high-speed syntheses are powerful tools for the discovery of new drugs. In particular, solid-phase organic synthesis (SPOS) is being widely used for the preparation of a large number of ...
Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives
(Molecular Diversity Preservation International, 2018-05)
The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis ...
Solid-phase Petasis multicomponent reaction for the generation of beta-lactams 3-substituted with non-proteinogenic alfa-amino acids
(Elsevier, 2013-07)
An efficient protocol for the rapid generation of libraries of biologically promising b-lactams is described. Key step is a solid-phase based multicomponent Petasis reaction
Mechanochemical synthesis, characterization and thermoanalytical study of a new curcumin derivative
(2020-01-01)
The curcumin is the major constituent of turmeric plant (Curcuma longa), which presents several biological activities such as antioxidant, bactericidal, anti-inflammatory and antitumor. An interesting strategy to improve ...
Solid-supported cross-metathesis and a formal alkane metathesis for the generation of biologically relevant molecules
(American Chemical Society, 2015-02)
Solid-phase synthetic strategies towards the generation of libraries of biologically relevant molecules were developed using olefin cross-metathesis as a key step. It is remarkably the formal alkane metathesis based on a ...