Now showing items 1-10 of 320
Interaction between brain L-type calcium channels and alpha(2)-adrenoceptors in the inhibition of sodium appetite
(Elsevier B.V., 2002-03-22)
Calcium channels mediate the actions of many drugs. The present work investigated whether diltiazem, an L-type calcium channel blocker, alters the inhibition of sodium appetite induced by noradrenaline and the alpha(2)-a ...
Anestésicos locais: interação com membranas biológicas e com o canal de sódio voltagem-dependente
(Sociedade Brasileira de Química, 2008-01-01)
Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the ...
Effects of beta-adrenoceptor antagonists in the neural nitric oxide release induced by electrical field stimulation and sodium channel activators in the rabbit corpus cavemosum
(Elsevier Science BvAmsterdamHolanda, 2005)
Molecular determinants of binding of a wasp toxin (PMTXs) and its analogs in the Na+ channels proteins
(Elsevier B.V., 2000-05-05)
The structural specificity of alpha-PMTX, a novel peptide toxin derived from wasp venom has been studied on the neuromuscular synapse in the walking leg of the lobster. alpha-PMTX is known to induce repetitive action ...
ABNORMAL EXPRESSION OF VOLTAGE-GATED SODIUM CHANNELS Nav1.7, Nav1.3 AND Nav1.8 IN TRIGEMINAL NEURALGIA
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
Voltage-gated sodium channels have been implicated in acute and chronic neuropathic pain. Among subtypes, Nav1.7 single mutations can cause congenital indifference to pain or chronic neuropathic pain syndromes, including ...