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Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA
(2013)
Cisplatin is one of the most effective and widely used chemotherapeutic agents against several types of human cancers. However, the underlying mechanisms of action are not fully understood. We aimed to investigate the ...
Inhibition of basal JNK activity by small interfering RNAs enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells
(Spandidos Publications, 2015)
Inhibition of basal Jun kinase (JNK) activity by small interfering RNAs (siRNAs) enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells. Although the JNK pathway has been extensively studied in ...
Interferência por RNA: uma nova alternativa para terapia nas doenças reumáticas
(Sociedade Brasileira de Reumatologia, 2010-12-01)
RNA interference (RNAi) is a post-transcriptional gene silencing mechanism preserved during evolution. This mechanism, recently described, is mediated by small double-stranded RNAs (dsRNAs) that can specifically recognize ...
Targeting focal adhesion kinase with small interfering RNA prevents and reverses load-induced cardiac hypertrophy in mice
(Lippincott Williams & WilkinsPhiladelphiaEUA, 2007)
siARN y shARN: Aspectos básicos y aplicados : su uso como agentes terapéuticossiRNA and shRNA: basic and applied aspects : their use as therapeutic agentssiARN e shARN: aspectos básicos e aplicados : seu uso como agentes terapêuticos
(Federación Bioquímica de la Provincia Buenos Aires, 2011-12)
La interferencia del ARN es un fenómeno por el cual pequeñas moléculas de ARN doble cadena inhiben la expresión génica de manera secuencia específica. Esta vía se encuentra altamente conservada en los organismos eucariotas. ...
Silencing of HTLV-1 gag and env genes by small interfering RNAs in HEK 293 cells
(ELSEVIER SCIENCE BV, 2011)
Since the discovery of RNAi technology, several functional genomic and disease therapy studies have been conducted using this technique in the field of oncology and virology. RNAi-based antiviral therapies are being studied ...