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Protein Repeats from First Principles
(Nature Publishing Group, 2016-04)
Some natural proteins display recurrent structural patterns. Despite being highly similar at the tertiary structure level, repeating patterns within a single repeat protein can be extremely variable at the sequence level. ...
Genetic Diversity of Mycobacterium avium sp. Paratuberculosis by Mycobacterial Interspersed Repetitive Unit–Variable Number Tandem Repeat and Multi‑Locus Short‑Sequence Repeat One‑Sentence Summary: Genetic Diversity of Mycobacterium avium sp. Paratuberculosis Isolates
(Medknow Publications, 2021-03)
Background: Paratuberculosis is an enteric disease caused by Mycobacterium avium sp. paratuberculosis (MAP) that affects mainly ruminant producing losses to the livestock industry. Many molecular epidemiological methods ...
Non-tandem repeat polymorphisms at microsatellite loci in wine yeast species
(Springer Heidelberg, 2020-05)
Yeast microsatellite loci consist of short tandem-repeated DNA sequences of variable length. The high mutational rate at these loci generates a remarkable repertoire of alleles, useful for strain differentiation and ...
Complex Energy Landscape of a Giant Repeat Protein
(Cell Press, 2013-11)
Here, we reveal a remarkable complexity in the unfolding of giant HEAT-repeat protein PR65/A, a molecular adaptor for the heterotrimeric PP2A phosphatases. The repeat array ruptures at multiple sites, leading to intermediate ...
The complete organelle genomes of Physochlaina orientalis: Insights into short sequence repeats across seed plant mitochondrial genomes
(Academic Press Inc Elsevier Science, 2019-08)
Short repeats (SR)play an important role in shaping seed plant mitochondrial genomes (mtDNAs). However, their origin, distribution, and relationships across the different plant lineages remain unresolved. We focus on the ...
Large Ankyrin repeat proteins are formed with similar and energetically favorable units
(Public Library of Science, 2020-06)
Ankyrin containing proteins are one of the most abundant repeat protein families present in all extant organisms. They are made with tandem copies of similar amino acid stretches that fold into elongated architectures. ...
Prevalence of C9orf72 hexanucleotide repeat expansion in Greek patients with sporadic ALS
(Taylor & Francis, 2020-07)
A total of 178 consecutive patients with definite sALS without frontotemporal dementia (FTD) were enrolled in this study, after complete clinical evaluation. A Repeat-Primed Polymerase Chain Reaction (RP-PCR) protocol was ...
Folding kinetics of the cooperatively folded subdomain of the IκBα ankyrin repeat domain
(Academic Press Ltd - Elsevier Science Ltd, 2011-04)
The ankyrin repeat (AR) domain of IκBα consists of a cooperative folding unit of roughly four ARs (AR1-AR4) and of two weakly folded repeats (AR5 and AR6). The kinetic folding mechanism of the cooperative subdomain, IκBα ...
Molecular dynamics simulations on interaction of ssDNA-causing DM1 with carbon and boron nitride nanotubes to inhibit the formation of CTG repeat secondary structures
(Elsevier Science, 2020-09-15)
Exposure of genomic, single-stranded DNA (ssDNA) during transcription and replication creates opportunities for the formation of inappropriate secondary structures. CTG repeat has been shown to form stable secondary ...
Genotyping of Leptospira interrogans strains from Argentina by Multiple-Locus Variable-number tandem repeat Analysis (MLVA)
(Elsevier, 2011-03)
Leptospirosis outbreaks occur regularly in Argentina and other South American countries, but little is known about their epidemiological relationships. Application of new molecular tools, such as the Multiple-Locus ...