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Platelets in wound healing and regenerative medicine
(Taylor & Francis Ltd, 2018-08)
Although platelets are widely recognized as having a critical role in primary hemostasis and thrombosis, increasing experimental and clinical evidence identifies these enucleated cells as relevant modulators of other ...
Regenerative Medicine for the Aging Brain
(Enliven, 2014-12)
In the central nervous system, cholinergic and dopaminergic (DA) neurons are among the cells most susceptible to the deleterious effects of age. Thus, the basal forebrain cholinergic system is known to undergo moderate ...
An optimised protocol for platelet-rich plasma preparation to improve its angiogenic and regenerative properties
(Nature Publishing Group, 2018-12)
Although platelet-rich plasma (PRP) is used as a source of growth factors in regenerative medicine, its effectiveness remains controversial, partially due to the absence of PRP preparation protocols based on the regenerative ...
Regulatable adenovector harboring the GFP and Yamanaka genes for implementing regenerative medicine in the brain
(Nature Publishing Group, 2019-11)
Biological rejuvenation by partial cell reprogramming is an emerging avenue of research. In this context, regulatable pluripotency gene expression systems are the most widely used at present. We have constructed a regulatable ...
Improving the Therapeutic Ability of Mesenchymal Stem/Stromal Cells for the Treatment of Conditions Influenced by Immune Cells
(Hindawi Publishing Corporation, 2021-02)
Currently, mesenchymal stem/stromal cells (MSCs) are among the most used cells in clinical trials. Whereas many characteristics of these cells have been described to date, aspects of their basic biology that may have an ...
Anticoagulants interfere with the angiogenic and regenerative responses mediated by platelets
(Frontiers Media, 2020-03-20)
Background and aims: Platelet rich plasma (PRP) obtained from blood anticoagulated with acid-citrate-dextrose (ACD) or sodium-citrate (SC) is used for regenerative medicine as source of platelet-derived growth factors. ...
PRP in wound healing applications
(Taylor & Francis Ltd, 2020-11)
Platelets play a crucial role in hemostasis, tissue regeneration and host defense. Based on these settings, platelet-rich plasma (PRP) and its derivatives are therapeutically used to promote wound healing in several ...
Global Diversification in Medicine Regulation: Insights from Regenerative Stem Cell Medicine
(Routledge, 2018-12)
Medicine regulation worldwide has undergone a process of regulatory diversification. The evidence-based medicine (EBM) paradigm, centered on multi-phase randomized controlled trials, is increasingly contested and replaced ...
Design and characterization of microspheres for a 3D mesenchymal stem cell culture
(Elsevier Science, 2020-12)
Recent studies have shown the relevance of growing mesenchymal stem cells (MSCs) in three-dimensional environments with respect to the monolayer cell culture on an adherent substrate. In this sense, macroporous scaffolds ...
Células Madre Mesenquimales y Medicina Regenerativa en la Cirrosis HepáticaMesenchymal stem cells and regenerative medicine in liver cirrhosis
(Medicina (Buenos Aires), 2017-06)
Las células madre mesenquimales (MSCs) son células multipotentes con capacidad de auto-renovación, presentes en diferentes tejidos del organismo. En los últimos años se ha avanzado significativamente en su estudio debido ...