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Actin Filaments—A Target for Redox Regulation
(Wiley, 2016)
Actin and its ability to polymerize into dynamic filaments is
critical for the form and function of cells throughout the
body. While multiple proteins have been characterized as
affecting actin dynamics through noncovalent ...
Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease
(Elsevier, 2020)
Aging is a natural process that includes several changes that gradually make organisms degenerate and die. Harman's theory proposes that aging is a consequence of the progressive accumulation of oxidative modifications ...
Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart
(American Physiological Society, 2016)
Previous results from our laboratory showed that phosphorylation of ryanodine receptor 2 (RyR2) by Ca2+ calmodulin-dependent kinase II (CaMKII) was a critical but not the unique event responsible for the production of ...
Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking
(Frontiers Media, 2015)
A proper balance between chemical reduction and oxidation (known as redox balance)
is essential for normal cellular physiology. Deregulation in the production of oxidative
species leads to DNA damage, lipid peroxidation ...
Modification of Silicon Surface with Redox Molecules Derived from Ferrocene
(2010)
This study presents a new method to bind active redox molecules derived of ferrocene to the surface of single crystal silicon. The procedure consists in the reaction of hydrogenated silicon with allyl bromide activated ...
High fat diet induced obesity produces spontaneous ventricular arrhythmias and increases the activity of ryanodine receptors in mice
(MDPI, 2018)
Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), the calcium release channels of the sarcoplasmic reticulum, ...
Preconditioning tachycardia decreases the activity of the mitochondrial permeability transition pore in the dog heart
(2011)
Cardioprotection by preconditioning is a central issue of current research on heart function. Several reports indicate that preventing the assembly and opening of the mitochondrial permeability transition pore (mPTP) ...
Ischemia Enhances Activation by Ca2+ and Redox Modification of Ryanodine Receptor Channels from Rat Brain Cortex
(2008)
Cerebral ischemia stimulates Ca2+influx and thus increases neuronal intracellular free [Ca2+. Using a rat model of cerebral ischemia
without recirculation, we tested whether ischemia enhances the activation by Ca2+ of ...
Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2006-12-29)
The skeletal muscle Ca2+-release channel ( ryanodine receptor type 1 (RyR1)) is a redox sensor, susceptible to reversible S-nitrosylation, S-glutathionylation, and disulfide oxidation. So far, Cys-3635 remains the only ...