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Characterization of the mechanisms underlying the crosstalk between galectins and notch in gastric cancer
(London, 2013)
Gastric cancer is the fourth most common cancer and the second leading cause of cancer-related deaths worldwide. Galectins form a family of β-galactosides binding proteins that recognize a variety of glycan-containing ...
Dampening the signals transduced through hedgehog via microRNA miR-7 facilitates Notch-induced tumourigenesis
(Public Library Science, 2013-05-07)
Fine-tuned Notch and Hedgehog signaling pathways via attenuators and dampers have long been recognized as important<br />mechanisms to ensure the proper size and differentiation of many organs and tissues. This notion is ...
A link between Notch and progesterone maintains the functionality of the rat corpus luteum
(Bioscientifica, 2015-01)
In this study, we investigated the interaction between the Notch pathway and progesterone to maintain the functionality of the corpus luteum(CL).WhenNotch signaling is activated, the g-secretase complex releases the active ...
Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries
(Impact Journals LLC, 2017-07)
Pituitary adenomas are among the most frequent intracranial neoplasms andtreatment depends on tumor subtype and clinical features. Unfortunately, nonresponder cases occur, then new molecular targets are needed.Notch system ...
Neurotrophins acting via TRKB receptors activate the JAGGED1-NOTCH2 cell-cell communication pathway to facilitate early ovarian development
(2011)
Tropomyosin-related kinase (TRK) receptor B (TRKB) mediates the supportive actions of neurotrophin 4/5 and brain-derived neurotrophic factor on early ovarian follicle development. Absence of TRKB receptors reduces granulosa ...
The dicrotic notch analyzed by a numerical model
(Pergamon-Elsevier Science Ltd, 2016-05)
Divergent concepts on the origin of the dicrotic notch are widespread in medical literature and education. Since most medical textbooks explain the origin of the dicrotic notch as caused by the aortic valve closure itself, ...
The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling
(2016-01-28)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy that preferentially affects children and adolescents. Over 50% of human T-ALLs possess activating mutations of Notch1. The clerodane ...
TGF-β pro-oligodendrogenic effects on adult SVZ progenitor cultures and its interaction with the Notch signaling pathway
(Wiley-liss, Div John Wiley & Sons Inc, 2018-02)
Adult neural progenitor cells (NPCs) are capable of differentiating into neurons, astrocytes, and oligodendrocytes throughout life. Notch and transforming growth factor β1 (TGF‐β) signaling pathways play critical roles in ...
Drosophila glial glutamate transporter Eaat1 is regulated by fringe-mediated notch signaling and is essential for larval locomotion
(Society For Neuroscience, 2010-10)
In the mammalian CNS, glial cells expressing excitatory amino acid transporters (EAATs) tightly regulate extracellular glutamate levels to control neurotransmission and protect neurons from excitotoxic damage. Dysregulated ...
Mycobacterium tuberculosis TLR2 agonists LprA, LM and Man-LAM induce notch1 and socs3 transcription
(Academic Journals, 2011)